Body weight management effect of burdock (Arctium lappa L.) root is associated with the activation of AMP-activated protein kinase in human HepG2 cells

Daih Huang Kuo, Ming Chi Hung, Chao Ming Hung, Li Min Liu, Fu An Chen, Po Chuen Shieh, Chi Tang Ho, Tzong Der Way

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Burdock (Arcticum lappa L.) root is used in folk medicine and also as a vegetable in Asian countries. In the present study, burdock root treatment significantly reduced body weight in rats. To evaluate the bioactive compounds, we successively extracted the burdock root with ethanol (AL-1), and fractionated it with n-hexane (AL-2), ethyl acetate (AL-3), n-butanol (AL-4), and water (AL-5). Among these fractions, AL-2 contained components with the most effective hypolipidemic potential in human hepatoma HepG2 cells. AL-2 decreased the expression of fatty acid synthase (FASN) and inhibited the activity of acetyl-coenzyme A carboxylase (ACC) by stimulating AMP-activated protein kinase (AMPK) through the LKB1 pathway. Three active compounds were identified from the AL-2, namely α-linolenic acid, methyl α-linolenate, and methyl oleate. These results suggest that burdock root is expected to be useful for body weight management.

Original languageEnglish (US)
Pages (from-to)1320-1326
Number of pages7
JournalFood Chemistry
Volume134
Issue number3
DOIs
StatePublished - Oct 1 2012

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

Keywords

  • ACC
  • AMPK
  • Body weight management
  • Burdock root
  • FASN

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