Bone involvement in Hodgkin's disease

Lee N. Newcomer, Martin B. Silverstein, E. C. Cadman, Leonard R. Farber, Joseph Bertino, Leonard R. Prosnitz

Research output: Contribution to journalArticle

45 Scopus citations


Eighteen patients with osseous involvement were identified from a series of 124 consecutive patients treated with combined‐modality therapy with advanced‐stage or relapsing Hodgkin's disease. Multiple lesions were seen as frequently as were solitary lesions. Nodular sclerosing histology was as prevalent as mixed cellularity disease. However, those five cases initially diagnosed at protocol entry were predominantly mixed cellularity (80%) with multiple lesions (80%). Sites of involvement included: the spine, 24; pelvis, 8; ribs, 4; femur, 3; skull, 1; and shoulder 1. Actuarial survival for these patients was 84% at nine years. Only three patients were induction failures and no patient has had a relapse. Patients with bone lesions had favorable responses to combined‐modality therapy.

Original languageEnglish (US)
Pages (from-to)338-342
Number of pages5
Issue number2
StatePublished - Jan 1 1982
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Newcomer, L. N., Silverstein, M. B., Cadman, E. C., Farber, L. R., Bertino, J., & Prosnitz, L. R. (1982). Bone involvement in Hodgkin's disease. Cancer, 49(2), 338-342.<338::AID-CNCR2820490221>3.0.CO;2-I