Brain aminergic axons exhibit marked variability in conduction velocity

Gary Aston Jones, Menahem Segal, Floyd E. Bloom

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Impulses in rat locus coeruleus neurons exhibit pronounced conduction latency decreases, followed by even larger latency increases (of over 20 msec in some cases) during a single train of antidromic activation. The magnitude of latency fluctuation varies as a function of basal antidromic latency, frequency of stimulation, and number of stimuli in a train. These and additional data indicate that this variability in latency is a consequence of altered impulse conduction velocity along the axons, perhaps reflecting reduced ion concentration gradients resulting from impulse propagation. These latency changes may allow thin unmyelinated axons to influence target cells most effectively with short bursts of activity, and suggest that myelination and large axon diameter provide for high fidelity as well as for high velocity of impulse flow in nervous tissue.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalBrain research
Volume195
Issue number1
DOIs
StatePublished - Aug 11 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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