Brain cell surface antigens detected by anti-corpus callosum antiserum

M. Schachner, K. A. Wortham, M. Z. Ryberg, S. Dorfman, G. Le M. Campbell

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

When rabbits are injected with tissue homogenates of white matter from bovine corpus callosum, an antiserum is produced which reacts with the surface membrane of 20-30% of all cells obtained by trypsin-dissociation of cerebellum from 10-day-old mice. The antigen or set of antigens recognized by this antiserum is detectable on embryonic, early postnatal, and adult mouse brain, but not on liver, spleen, kidney, thymus and sperm. The antigen is expressed in different regions of the brain and also, in decreased amounts, on retina. In histological sections of cerebellum from 21-day-old mice the antigen is predominantly localized in white matter tracts. Whereas nervous tissue from chicken and rabbit does not carry detectable levels of the antigen, rat, bovine and human brains are antigen-positive.

Original languageEnglish (US)
Pages (from-to)87-97
Number of pages11
JournalBrain research
Volume127
Issue number1
DOIs
StatePublished - May 20 1977
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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