TY - JOUR
T1 - Brain cell surface antigens detected by anti-corpus callosum antiserum
AU - Schachner, M.
AU - Wortham, K. A.
AU - Ryberg, M. Z.
AU - Dorfman, S.
AU - Campbell, G. Le M.
N1 - Funding Information:
This research was supported by the National Science Foundation (GB-34186), National Foundation-March of Dimes, Wolbach Fund, Deutsche Forschungs-gemeinschaft, and USPHS Grants CA-10815 from the National Cancer Institute, GM-00281 from the Institute of General Medical Sciences, and NS-11037 from the National Institute of Neurological Diseases and Stroke, and the National Multiple Sclerosis Society (974-A-2).
PY - 1977/5/20
Y1 - 1977/5/20
N2 - When rabbits are injected with tissue homogenates of white matter from bovine corpus callosum, an antiserum is produced which reacts with the surface membrane of 20-30% of all cells obtained by trypsin-dissociation of cerebellum from 10-day-old mice. The antigen or set of antigens recognized by this antiserum is detectable on embryonic, early postnatal, and adult mouse brain, but not on liver, spleen, kidney, thymus and sperm. The antigen is expressed in different regions of the brain and also, in decreased amounts, on retina. In histological sections of cerebellum from 21-day-old mice the antigen is predominantly localized in white matter tracts. Whereas nervous tissue from chicken and rabbit does not carry detectable levels of the antigen, rat, bovine and human brains are antigen-positive.
AB - When rabbits are injected with tissue homogenates of white matter from bovine corpus callosum, an antiserum is produced which reacts with the surface membrane of 20-30% of all cells obtained by trypsin-dissociation of cerebellum from 10-day-old mice. The antigen or set of antigens recognized by this antiserum is detectable on embryonic, early postnatal, and adult mouse brain, but not on liver, spleen, kidney, thymus and sperm. The antigen is expressed in different regions of the brain and also, in decreased amounts, on retina. In histological sections of cerebellum from 21-day-old mice the antigen is predominantly localized in white matter tracts. Whereas nervous tissue from chicken and rabbit does not carry detectable levels of the antigen, rat, bovine and human brains are antigen-positive.
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U2 - 10.1016/0006-8993(77)90381-X
DO - 10.1016/0006-8993(77)90381-X
M3 - Article
C2 - 861755
AN - SCOPUS:84886622225
VL - 127
SP - 87
EP - 97
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -