Brain responses to tonal changes in the first two years of life

Hongkui Jing, April A. Benasich

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Maturation of auditory perceptual and discrimination process within the first two years of life is investigated in healthy infants by examining event-related potentials (ERPs). High-density EEG signals were recorded from the scalp monthly between 3 and 24 months of age. Two types of stimuli (100 vs. 100 Hz for standard stimuli; 100 vs. 300 Hz for deviant stimuli; occurrence rate: 85:15%) were presented using an oddball paradigm. Latencies and amplitudes were compared across development. The results showed that latencies of P 150, N250, P350, and N450 components gradually decreased with increasing age. Amplitudes of the N250 and P350 components gradually increased and reached the maximum at 9 months, and then gradually decreased with the increase of age. Mismatch negativity was not obvious at 3 months of age, but was seen at 4-5 months and became robust after 6 months. Robust late positivity was recorded at all ages. These mismatch responses were noticeable in the frontal, central, and parietal areas, and the maximal MMN amplitude distribution gradually moved from the parietal area to the frontal area across the age range. Two important periods - one around 6 months and the other around 9 months are suggested in the maturation of auditory central system. Dynamical changes in the underlying source strengths and orientations may be principal contributors to ERP morphological changes in infants within the first 24 months.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalBrain and Development
Volume28
Issue number4
DOIs
StatePublished - May 2006

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Keywords

  • Auditory event-related potentials
  • Child
  • Development
  • EEG
  • Mismatch negativity

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