BRCA1 and BRCA2 germline mutations in lymphoma patients

Orit Yossepowitch, Narciso Olvera, Jaya M. Satagopan, Helen Huang, Sabrina Jhanwar, Beth Rapaport, Jeff Boyd, Kenneth Offit

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Mutations in the BRCA1 and BRCA2 tumor suppressor genes are associated with an increased risk for breast and ovarian cancers as well as other types of malignancies. The observation of a germline BRCA1 mutation in an index case with a lymphoid neoplasm in the setting of a family history of breast cancer prompted us to explore the role of BRCA germline mutations as lymphoma susceptibility alleles. A panel of 286 DNA samples from Jewish lymphoma patients was analyzed for the three most frequent BRCA1 and BRCA2 germline mutations in those of Ashkenazi Jewish heritage, and compared to a cohort of 5010 DNA samples from healthy controls. Of the 286 cases, 2 patients carried a germline BRCA mutation; Both were diagnosed at an early age with an intermediate grade non-Hodgkin's lymphoma. This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalLeukemia and Lymphoma
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Keywords

  • BRCA1
  • BRCA2
  • Breast
  • Leukemia
  • Lymphoma
  • Mutation

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