BRCA1 and PALB2 in a messy breakup

Joonyoung Her, Samuel F. Bunting

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations in the BRCA1 gene cause an extremely high lifetime risk of breast and ovarian cancer, but the exact mechanism by which the BRCA1 protein acts to prevent cancer onset remains unclear. In this edition of Cancer Research, Park and colleagues describe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA1. This change prevents BRCA1 from interacting with PALB2 (partner and localizer of BRCA2), causing rapid cancer onset and a loss of blood cells similar to Fanconi anemia.

Original languageEnglish (US)
Pages (from-to)4044-4045
Number of pages2
JournalCancer Research
Volume80
Issue number19
DOIs
StatePublished - Oct 1 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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