Brief report: Brain activation to social words in a sedated child with autism

Dennis P. Carmody, Rosanne Moreno, Audrey E. Mars, Kapila Seshadri, George H. Lambert, Michael Lewis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A functional magnetic resonance imaging (fMRI) study was performed on a 4-year-old girl with autism. While sedated, she listened to three utterances (numbers, hello, her own first name) played through headphones. Based on analyses of the fMRI data, the amount of total brain activation varied with the content of the utterance. The greatest volume of overall activation was in response to numbers, followed by the word 'hello', with the least activation to her name. Frontal cortex activation was greatest in response to her name, with less activation for numbers, and the least for the word 'hello.' These findings indicate that fMRI can identify and quantify the brain regions that are activated in response to words in children with autism under sedation.

Original languageEnglish (US)
Pages (from-to)1381-1385
Number of pages5
JournalJournal of Autism and Developmental Disorders
Volume37
Issue number7
DOIs
StatePublished - Aug 2007

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology

Keywords

  • Autism
  • Self-awareness
  • fMRI

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