Bronchial hyperresponsiveness: Insights into new signaling molecules

Yassine Amrani, Omar Tliba, Deepak A. Deshpande, Timothy F. Walseth, Mathur S. Kannan, Reynold Panettieri

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Signaling molecules play a critical role in the pathophysiology of airway diseases. Recent evidence shows that cyclic ADP-ribose (cADPr), an endogenous activator of the ryanodine receptor channel in mammalian cells, modulates agonist-induced calcium responses in airway smooth muscle (ASM) cells. In addition, cADPr-mediated calcium release appears to play an important role in the 'non-specific' increased ASM responsiveness to contractile agonists in cytokine-treated cells, a characteristic finding of asthma. Furthermore, other signaling molecules such as Rho/Rho kinase and phosphodiesterase also contribute to bronchial hyperresponsiveness. Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume4
Issue number3
DOIs
StatePublished - Jan 1 2004

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Cyclic ADP-Ribose
Smooth Muscle
Calcium
rho-Associated Kinases
Ryanodine Receptor Calcium Release Channel
Calcium Signaling
Phosphoric Diester Hydrolases
Smooth Muscle Myocytes
Asthma
Cytokines
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Amrani, Yassine ; Tliba, Omar ; Deshpande, Deepak A. ; Walseth, Timothy F. ; Kannan, Mathur S. ; Panettieri, Reynold. / Bronchial hyperresponsiveness : Insights into new signaling molecules. In: Current Opinion in Pharmacology. 2004 ; Vol. 4, No. 3. pp. 230-234.
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Bronchial hyperresponsiveness : Insights into new signaling molecules. / Amrani, Yassine; Tliba, Omar; Deshpande, Deepak A.; Walseth, Timothy F.; Kannan, Mathur S.; Panettieri, Reynold.

In: Current Opinion in Pharmacology, Vol. 4, No. 3, 01.01.2004, p. 230-234.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Bronchial hyperresponsiveness

T2 - Insights into new signaling molecules

AU - Amrani, Yassine

AU - Tliba, Omar

AU - Deshpande, Deepak A.

AU - Walseth, Timothy F.

AU - Kannan, Mathur S.

AU - Panettieri, Reynold

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AB - Signaling molecules play a critical role in the pathophysiology of airway diseases. Recent evidence shows that cyclic ADP-ribose (cADPr), an endogenous activator of the ryanodine receptor channel in mammalian cells, modulates agonist-induced calcium responses in airway smooth muscle (ASM) cells. In addition, cADPr-mediated calcium release appears to play an important role in the 'non-specific' increased ASM responsiveness to contractile agonists in cytokine-treated cells, a characteristic finding of asthma. Furthermore, other signaling molecules such as Rho/Rho kinase and phosphodiesterase also contribute to bronchial hyperresponsiveness. Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness.

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