Bupropion/nortriptyline combination for refractory depression

J. T. Apter, S. F. Kushner, R. L. Woolfolk

Research output: Contribution to journalArticle

8 Scopus citations


Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalAnnals of Clinical Psychiatry
Issue number4
StatePublished - Jan 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health


  • Bupropion
  • Nortriptyline
  • Refractory depression

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