c-di-GMP displays A monovalent metal ion-dependent polymorphism

Zhaoying Zhang, Barbara L. Gaffney, Roger A. Jones

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Cyclic diguanosine monophosphate (c-di-GMP) is known to be an important signaling molecule that regulates the formation of bacterial biofilms. We demonstrate here by UV, CD, and NMR that it displays a surprising polymorphism that varies with the monovalent counterion and is consistent with the formation of a G-quartet structure in K+ and a stacked structure in Li+ or Na+. The ability of this rigid molecule to adopt different alignments may be important to its biological role.

Original languageEnglish (US)
Pages (from-to)16700-16701
Number of pages2
JournalJournal of the American Chemical Society
Issue number51
StatePublished - Dec 29 2004

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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