Cachexia: A systemic consequence of progressive, unresolved disease

Miriam Ferrer; Tracy G. Anthony; Janelle S. Ayres; Giulia Biffi; Justin C. Brown; Bette J. Caan; Elizabeth M. Cespedes Feliciano; Anthony P. Coll; Richard F. Dunne; Marcus D. Goncalves; Jonas Grethlein; Steven B. Heymsfield; Sheng Hui; Mariam Jamal-Hanjani; Jie Min Lam; David Y. Lewis; David McCandlish; Karen M. Mustian; Stephen O'Rahilly; Norbert Perrimon; Eileen P. White; Tobias Janowitz

doi:10.1016/j.cell.2023.03.028

Cachexia: A systemic consequence of progressive, unresolved disease

Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O'Rahilly, Norbert PerrimonEileen P. White, Tobias Janowitz

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.

Original language	English (US)
Pages (from-to)	1824-1845
Number of pages	22
Journal	Cell
Volume	186
Issue number	9
DOIs	https://doi.org/10.1016/j.cell.2023.03.028
State	Published - Apr 27 2023

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2023.03.028

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Ferrer, M., Anthony, T. G., Ayres, J. S., Biffi, G., Brown, J. C., Caan, B. J., Cespedes Feliciano, E. M., Coll, A. P., Dunne, R. F., Goncalves, M. D., Grethlein, J., Heymsfield, S. B., Hui, S., Jamal-Hanjani, M., Lam, J. M., Lewis, D. Y., McCandlish, D., Mustian, K. M., O'Rahilly, S., ... Janowitz, T. (2023). Cachexia: A systemic consequence of progressive, unresolved disease. Cell, 186(9), 1824-1845. https://doi.org/10.1016/j.cell.2023.03.028

@article{b56b6bd026864ffc894d6bfe28796e35,

title = "Cachexia: A systemic consequence of progressive, unresolved disease",

abstract = "Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.",

author = "Miriam Ferrer and Anthony, {Tracy G.} and Ayres, {Janelle S.} and Giulia Biffi and Brown, {Justin C.} and Caan, {Bette J.} and {Cespedes Feliciano}, {Elizabeth M.} and Coll, {Anthony P.} and Dunne, {Richard F.} and Goncalves, {Marcus D.} and Jonas Grethlein and Heymsfield, {Steven B.} and Sheng Hui and Mariam Jamal-Hanjani and Lam, {Jie Min} and Lewis, {David Y.} and David McCandlish and Mustian, {Karen M.} and Stephen O'Rahilly and Norbert Perrimon and White, {Eileen P.} and Tobias Janowitz",

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year = "2023",

month = apr,

day = "27",

doi = "10.1016/j.cell.2023.03.028",

language = "English (US)",

volume = "186",

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Ferrer, M, Anthony, TG, Ayres, JS, Biffi, G, Brown, JC, Caan, BJ, Cespedes Feliciano, EM, Coll, AP, Dunne, RF, Goncalves, MD, Grethlein, J, Heymsfield, SB, Hui, S, Jamal-Hanjani, M, Lam, JM, Lewis, DY, McCandlish, D, Mustian, KM, O'Rahilly, S, Perrimon, N, White, EP & Janowitz, T 2023, 'Cachexia: A systemic consequence of progressive, unresolved disease', Cell, vol. 186, no. 9, pp. 1824-1845. https://doi.org/10.1016/j.cell.2023.03.028

TY - JOUR

T1 - Cachexia

T2 - A systemic consequence of progressive, unresolved disease

AU - Ferrer, Miriam

AU - Anthony, Tracy G.

AU - Ayres, Janelle S.

AU - Biffi, Giulia

AU - Brown, Justin C.

AU - Caan, Bette J.

AU - Cespedes Feliciano, Elizabeth M.

AU - Coll, Anthony P.

AU - Dunne, Richard F.

AU - Goncalves, Marcus D.

AU - Grethlein, Jonas

AU - Heymsfield, Steven B.

AU - Hui, Sheng

AU - Jamal-Hanjani, Mariam

AU - Lam, Jie Min

AU - Lewis, David Y.

AU - McCandlish, David

AU - Mustian, Karen M.

AU - O'Rahilly, Stephen

AU - Perrimon, Norbert

AU - White, Eileen P.

AU - Janowitz, Tobias

PY - 2023/4/27

Y1 - 2023/4/27

N2 - Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.

AB - Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.

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DO - 10.1016/j.cell.2023.03.028

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AN - SCOPUS:85153052207

SN - 0092-8674

VL - 186

SP - 1824

EP - 1845

JO - Cell

JF - Cell

IS - 9

ER -

Cachexia: A systemic consequence of progressive, unresolved disease

Abstract

All Science Journal Classification (ASJC) codes

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