CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease

Seiichi Kato, Toshiro Sugiyama, Mineo Kudo, Kenji Ohnuma, Kyoko Ozawa, Kazuie Iinuma, Masahiro Asaka, Martin Blaser

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

cagA+ Helicobacter pylori strains have been linked to more severe gastric inflammation, peptic ulcer disease, and gastric cancer in adults, but there have been few studies of cagA in children. We examined the relationship between H. pylori cagA status and clinical status in Japanese children. Forty H. pylori-positive children were studied: 15 with nodular gastritis, 5 with gastric ulcers, and 20 with duodenal ulcers. H. pylori status was confirmed by biopsy-based tests and serum anti-H. pylori immunoglobulin G (IgG) antibody. As controls, 77 asymptomatic children with sera positive for anti- H. pylori IgG were enrolled. Levels of IgG antibodies to CagA in serum were measured by an antigen-specific enzyme-linked immunosorbent assay. In 16 patients with successful H. pylori eradication, posttreatment levels of CagA and H. priori IgG antibodies also were studied. The CagA antibody seropositivities of asymptomatic controls (81.8%) and patients with nodular gastritis, gastric ulcers, and duodenal ulcers (80.0 to 95.0%) were not significantly different. Compared with pretreatment levels of CagA antibodies, posttreatment levels decreased progressively and significantly. We conclude that, as in Japanese adults, a high prevalence of cagA+ H. pylori strains was found in Japanese children, and that there was no association with nodular gastritis or peptic ulcer disease. In the assessment of eradicative therapies, monitoring of serum anti-CagA antibodies does not appear to offer any direct benefit over monitoring of anti-H. pylori antibodies.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalJournal of Clinical Microbiology
Volume38
Issue number1
StatePublished - Jan 24 2000
Externally publishedYes

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Gastritis
Peptic Ulcer
Helicobacter pylori
Antibodies
Immunoglobulin G
Stomach Ulcer
Duodenal Ulcer
Serum
Stomach Neoplasms
Anti-Idiotypic Antibodies
Stomach
Enzyme-Linked Immunosorbent Assay
Inflammation
Biopsy
Antigens

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Kato, S., Sugiyama, T., Kudo, M., Ohnuma, K., Ozawa, K., Iinuma, K., ... Blaser, M. (2000). CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease. Journal of Clinical Microbiology, 38(1), 68-70.
Kato, Seiichi ; Sugiyama, Toshiro ; Kudo, Mineo ; Ohnuma, Kenji ; Ozawa, Kyoko ; Iinuma, Kazuie ; Asaka, Masahiro ; Blaser, Martin. / CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease. In: Journal of Clinical Microbiology. 2000 ; Vol. 38, No. 1. pp. 68-70.
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abstract = "cagA+ Helicobacter pylori strains have been linked to more severe gastric inflammation, peptic ulcer disease, and gastric cancer in adults, but there have been few studies of cagA in children. We examined the relationship between H. pylori cagA status and clinical status in Japanese children. Forty H. pylori-positive children were studied: 15 with nodular gastritis, 5 with gastric ulcers, and 20 with duodenal ulcers. H. pylori status was confirmed by biopsy-based tests and serum anti-H. pylori immunoglobulin G (IgG) antibody. As controls, 77 asymptomatic children with sera positive for anti- H. pylori IgG were enrolled. Levels of IgG antibodies to CagA in serum were measured by an antigen-specific enzyme-linked immunosorbent assay. In 16 patients with successful H. pylori eradication, posttreatment levels of CagA and H. priori IgG antibodies also were studied. The CagA antibody seropositivities of asymptomatic controls (81.8{\%}) and patients with nodular gastritis, gastric ulcers, and duodenal ulcers (80.0 to 95.0{\%}) were not significantly different. Compared with pretreatment levels of CagA antibodies, posttreatment levels decreased progressively and significantly. We conclude that, as in Japanese adults, a high prevalence of cagA+ H. pylori strains was found in Japanese children, and that there was no association with nodular gastritis or peptic ulcer disease. In the assessment of eradicative therapies, monitoring of serum anti-CagA antibodies does not appear to offer any direct benefit over monitoring of anti-H. pylori antibodies.",
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Kato, S, Sugiyama, T, Kudo, M, Ohnuma, K, Ozawa, K, Iinuma, K, Asaka, M & Blaser, M 2000, 'CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease', Journal of Clinical Microbiology, vol. 38, no. 1, pp. 68-70.

CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease. / Kato, Seiichi; Sugiyama, Toshiro; Kudo, Mineo; Ohnuma, Kenji; Ozawa, Kyoko; Iinuma, Kazuie; Asaka, Masahiro; Blaser, Martin.

In: Journal of Clinical Microbiology, Vol. 38, No. 1, 24.01.2000, p. 68-70.

Research output: Contribution to journalArticle

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AU - Blaser, Martin

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Kato S, Sugiyama T, Kudo M, Ohnuma K, Ozawa K, Iinuma K et al. CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease. Journal of Clinical Microbiology. 2000 Jan 24;38(1):68-70.