Caging metal ions with visible light-responsive nanopolymersomes

Julianne C. Griepenburg; Nimil Sood; Kevin B. Vargo; Dewight Williams; Jeff Rawson; Michael J. Therien; Daniel A. Hammer; Ivan J. Dmochowski

doi:10.1021/la5036689

Caging metal ions with visible light-responsive nanopolymersomes

Julianne C. Griepenburg, Nimil Sood, Kevin B. Vargo, Dewight Williams, Jeff Rawson, Michael J. Therien, Daniel A. Hammer, Ivan J. Dmochowski

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Polymersomes are bilayer vesicles that self-assemble from amphiphilic diblock copolymers, and provide an attractive system for the delivery of biological and nonbiological molecules due to their environmental compatibility, mechanical stability, synthetic tunability, large aqueous core, and hyperthick hydrophobic membrane. Herein, we report a nanoscale photoresponsive polymersome system featuring a meso-to-meso ethyne-bridged bis[(porphinato)zinc] (PZn₂) fluorophore hydrophobic membrane solute and dextran in the aqueous core. Upon 488 nm irradiation in solution or in microinjected zebrafish embryos, the polymersomes underwent deformation, as monitored by a characteristic red-shifted PZn₂ emission spectrum and confirmed by cryo-TEM. The versatility of this system was demonstrated through the encapsulation and photorelease of a fluorophore (FITC), as well as two different metal ions, Zn²⁺ and Ca²⁺.

Original language	English (US)
Pages (from-to)	799-807
Number of pages	9
Journal	Langmuir
Volume	31
Issue number	2
DOIs	https://doi.org/10.1021/la5036689
State	Published - Jan 20 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la5036689

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title = "Caging metal ions with visible light-responsive nanopolymersomes",

abstract = "Polymersomes are bilayer vesicles that self-assemble from amphiphilic diblock copolymers, and provide an attractive system for the delivery of biological and nonbiological molecules due to their environmental compatibility, mechanical stability, synthetic tunability, large aqueous core, and hyperthick hydrophobic membrane. Herein, we report a nanoscale photoresponsive polymersome system featuring a meso-to-meso ethyne-bridged bis[(porphinato)zinc] (PZn2) fluorophore hydrophobic membrane solute and dextran in the aqueous core. Upon 488 nm irradiation in solution or in microinjected zebrafish embryos, the polymersomes underwent deformation, as monitored by a characteristic red-shifted PZn2 emission spectrum and confirmed by cryo-TEM. The versatility of this system was demonstrated through the encapsulation and photorelease of a fluorophore (FITC), as well as two different metal ions, Zn2+ and Ca2+.",

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AU - Griepenburg, Julianne C.

AU - Sood, Nimil

AU - Vargo, Kevin B.

AU - Williams, Dewight

AU - Rawson, Jeff

AU - Therien, Michael J.

AU - Hammer, Daniel A.

AU - Dmochowski, Ivan J.

PY - 2015/1/20

Y1 - 2015/1/20

N2 - Polymersomes are bilayer vesicles that self-assemble from amphiphilic diblock copolymers, and provide an attractive system for the delivery of biological and nonbiological molecules due to their environmental compatibility, mechanical stability, synthetic tunability, large aqueous core, and hyperthick hydrophobic membrane. Herein, we report a nanoscale photoresponsive polymersome system featuring a meso-to-meso ethyne-bridged bis[(porphinato)zinc] (PZn2) fluorophore hydrophobic membrane solute and dextran in the aqueous core. Upon 488 nm irradiation in solution or in microinjected zebrafish embryos, the polymersomes underwent deformation, as monitored by a characteristic red-shifted PZn2 emission spectrum and confirmed by cryo-TEM. The versatility of this system was demonstrated through the encapsulation and photorelease of a fluorophore (FITC), as well as two different metal ions, Zn2+ and Ca2+.

AB - Polymersomes are bilayer vesicles that self-assemble from amphiphilic diblock copolymers, and provide an attractive system for the delivery of biological and nonbiological molecules due to their environmental compatibility, mechanical stability, synthetic tunability, large aqueous core, and hyperthick hydrophobic membrane. Herein, we report a nanoscale photoresponsive polymersome system featuring a meso-to-meso ethyne-bridged bis[(porphinato)zinc] (PZn2) fluorophore hydrophobic membrane solute and dextran in the aqueous core. Upon 488 nm irradiation in solution or in microinjected zebrafish embryos, the polymersomes underwent deformation, as monitored by a characteristic red-shifted PZn2 emission spectrum and confirmed by cryo-TEM. The versatility of this system was demonstrated through the encapsulation and photorelease of a fluorophore (FITC), as well as two different metal ions, Zn2+ and Ca2+.

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Caging metal ions with visible light-responsive nanopolymersomes

Abstract

All Science Journal Classification (ASJC) codes

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