Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

Sylvia Christakos, Leila J. Mady, Puneet Dhawan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We once viewed calbindin-D28K and calbindin-D9K as exclusively vitamin D-dependent proteins. It is now evident that the calbindins are not under the exclusive regulatory control of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3. Calbindin-D28K and calbindin-D9K are present in many different tissues and may serve many different functions. Accordingly, the regulation of these calcium-binding proteins is varied and quite complex. The calcium-selective epithelial calcium channels, transient receptor potential vanilloid 5 and 6 (TRPV5 and TRPV6), are colocalized with calbindin in the kidney and intestine, respectively. Studies in TRPV5 knockout (KO) mice have indicated that TRPV5 is important for renal calcium reabsorption. Calbindin-D28K interacts with TRPV5 and regulates its activity, suggesting a role for calbindin-D28K as a modulator of calcium influx. Studies using calbindin-D9k and TRPV6 KO mice suggest that in the KO mice there is compensation by another calcium channel or protein and that other factors involved in 1,25(OH)2D3-mediated intestinal calcium absorption remain to be identified.

Original languageEnglish (US)
Title of host publicationBiochemistry, Physiology and Diagnostics
PublisherElsevier Inc.
Pages343-359
Number of pages17
Volume1
ISBN (Electronic)9780128099667
ISBN (Print)9780128099650
DOIs
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Keywords

  • 1,25-Dihydroxyvitamin D
  • Apoptosis
  • Calbindin-D
  • Calbindin-D
  • Transient receptor potential vanilloid 5
  • Transient receptor vanilloid 6

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