Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

Sylvia Christakos; Leila J. Mady; Puneet Dhawan

doi:10.1016/B978-0-12-809965-0.00021-5

Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

Sylvia Christakos, Leila J. Mady, Puneet Dhawan

New Jersey Medical School (NJMS), Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

We once viewed calbindin-D_28K and calbindin-D_9K as exclusively vitamin D-dependent proteins. It is now evident that the calbindins are not under the exclusive regulatory control of 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃. Calbindin-D_28K and calbindin-D_9K are present in many different tissues and may serve many different functions. Accordingly, the regulation of these calcium-binding proteins is varied and quite complex. The calcium-selective epithelial calcium channels, transient receptor potential vanilloid 5 and 6 (TRPV5 and TRPV6), are colocalized with calbindin in the kidney and intestine, respectively. Studies in TRPV5 knockout (KO) mice have indicated that TRPV5 is important for renal calcium reabsorption. Calbindin-D_28K interacts with TRPV5 and regulates its activity, suggesting a role for calbindin-D_28K as a modulator of calcium influx. Studies using calbindin-D_9k and TRPV6 KO mice suggest that in the KO mice there is compensation by another calcium channel or protein and that other factors involved in 1,25(OH)₂D₃-mediated intestinal calcium absorption remain to be identified.

Original language	English (US)
Title of host publication	Biochemistry, Physiology and Diagnostics
Publisher	Elsevier Inc.
Pages	343-359
Number of pages	17
Volume	1
ISBN (Electronic)	9780128099667
ISBN (Print)	9780128099650
DOIs	https://doi.org/10.1016/B978-0-12-809965-0.00021-5
State	Published - Jan 1 2018

All Science Journal Classification (ASJC) codes

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Keywords

1,25-Dihydroxyvitamin D
Apoptosis
Calbindin-D
Calbindin-D
Transient receptor potential vanilloid 5
Transient receptor vanilloid 6

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10.1016/B978-0-12-809965-0.00021-5

Cite this

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title = "Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6",

abstract = "We once viewed calbindin-D28K and calbindin-D9K as exclusively vitamin D-dependent proteins. It is now evident that the calbindins are not under the exclusive regulatory control of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3. Calbindin-D28K and calbindin-D9K are present in many different tissues and may serve many different functions. Accordingly, the regulation of these calcium-binding proteins is varied and quite complex. The calcium-selective epithelial calcium channels, transient receptor potential vanilloid 5 and 6 (TRPV5 and TRPV6), are colocalized with calbindin in the kidney and intestine, respectively. Studies in TRPV5 knockout (KO) mice have indicated that TRPV5 is important for renal calcium reabsorption. Calbindin-D28K interacts with TRPV5 and regulates its activity, suggesting a role for calbindin-D28K as a modulator of calcium influx. Studies using calbindin-D9k and TRPV6 KO mice suggest that in the KO mice there is compensation by another calcium channel or protein and that other factors involved in 1,25(OH)2D3-mediated intestinal calcium absorption remain to be identified.",

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AB - We once viewed calbindin-D28K and calbindin-D9K as exclusively vitamin D-dependent proteins. It is now evident that the calbindins are not under the exclusive regulatory control of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3. Calbindin-D28K and calbindin-D9K are present in many different tissues and may serve many different functions. Accordingly, the regulation of these calcium-binding proteins is varied and quite complex. The calcium-selective epithelial calcium channels, transient receptor potential vanilloid 5 and 6 (TRPV5 and TRPV6), are colocalized with calbindin in the kidney and intestine, respectively. Studies in TRPV5 knockout (KO) mice have indicated that TRPV5 is important for renal calcium reabsorption. Calbindin-D28K interacts with TRPV5 and regulates its activity, suggesting a role for calbindin-D28K as a modulator of calcium influx. Studies using calbindin-D9k and TRPV6 KO mice suggest that in the KO mice there is compensation by another calcium channel or protein and that other factors involved in 1,25(OH)2D3-mediated intestinal calcium absorption remain to be identified.

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KW - Transient receptor potential vanilloid 5

KW - Transient receptor vanilloid 6

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ER -

Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

Abstract

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