TY - JOUR
T1 - Calcium and heart failure
T2 - How did we get here and where are we going?
AU - Siri‐angkul, Natthaphat
AU - Dadfar, Behzad
AU - Jaleel, Riya
AU - Naushad, Jazna
AU - Parambathazhath, Jaseela
AU - Doye, Angelia A.
AU - Xie, Lai Hua
AU - Gwathmey, Judith K.
N1 - Funding Information:
The research presented has been supported by the American Heart Association as well as the National Science Foundation to JKG. Intramural funding was provided by the Beth Israel Dea-coness Medical Center, Harvard Medical School, Boston, MA, to JKG. JKG has been supported by R01‐HL49574; R01‐HL49574; and R01‐HL39091. LHX has been supported by National Institutes of Health (R01s HL97979 and HL133294 and the American Heart Association (19TPA34900003). NS has been supported by the Prince Mahidol Award Youth Program (PMAYP) Scholarship from the Prince Mahidol Award Foundation, Thailand. Acknowledgments: The authors wish to thank all of the heart transplant donors as well as the fam-ilies of donors of non‐failing hearts. We also wish to acknowledge the experimental animals used in these studies, which were kept to a minimum.
Funding Information:
Funding: The research presented has been supported by the American Heart Association as well as the National Science Foundation to JKG. Intramural funding was provided by the Beth Israel Dea‐ coness Medical Center, Harvard Medical School, Boston, MA, to JKG. JKG has been supported by R01‐HL49574; R01‐HL49574; and R01‐HL39091. LHX has been supported by National Institutes of Health (R01s HL97979 and HL133294 and the American Heart Association (19TPA34900003). NS has been supported by the Prince Mahidol Award Youth Program (PMAYP) Scholarship from the Prince Mahidol Award Foundation, Thailand.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/2
Y1 - 2021/7/2
N2 - The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 seconds from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches.
AB - The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 seconds from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches.
KW - Beta blocker
KW - Calcium tran-sient
KW - Excitation–contraction coupling
KW - Heart failure
KW - Hypoxia
KW - Inotrope
KW - Myocardial contractility
KW - Myofilament
KW - Sarcoplasmic reticulum
KW - Sarcoplasmic reticulum Ca ATPase
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U2 - 10.3390/ijms22147392
DO - 10.3390/ijms22147392
M3 - Review article
C2 - 34299010
AN - SCOPUS:85109266533
SN - 1661-6596
VL - 22
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 14
M1 - 7392
ER -