Calcium-Buffering Proteins: Calbindin

L. J. Mady; F. Haleem; S. Christakos

doi:10.1016/B978-0-12-378630-2.00228-0

Calcium-Buffering Proteins: Calbindin

L. J. Mady, F. Haleem, S. Christakos

New Jersey Medical School (NJMS), Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The calbindins, calbindin-D_9k and calbindin-D_28k, belong to a family of high-affinity calcium-binding proteins characterized by the EF hand structural motif. Calbindin was the first identified target of vitamin D action. It is now known that the calbindins are not exclusively regulated by vitamin D. They are present in many different tissues, serve different functions, and are regulated by factors other than 1,25(OH)₂D₃. Calbindin-D_28k is highly conserved in evolution. Calbindin-D_9k, however, is present only in mammals. Evidence suggests that calbindin-D_28k is involved in protection against apoptotic cell death by buffering calcium and by inhibiting caspase-3. Additional functions of calbindin include maintenance of intracellular calcium homeostasis and modulation of calcium influx.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	284-289
Number of pages	6
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00228-0
State	Published - Feb 15 2013

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

Keywords

1,25-dihydroxyvitamin D [1,25(OH)D]
Apoptosis
Calbindin-D
Calbindin-D
Calcium
Intestine
Kidney
Knockout mice
Nervous tissue
Regulation
Vitamin D

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10.1016/B978-0-12-378630-2.00228-0

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title = "Calcium-Buffering Proteins: Calbindin",

abstract = "The calbindins, calbindin-D9k and calbindin-D28k, belong to a family of high-affinity calcium-binding proteins characterized by the EF hand structural motif. Calbindin was the first identified target of vitamin D action. It is now known that the calbindins are not exclusively regulated by vitamin D. They are present in many different tissues, serve different functions, and are regulated by factors other than 1,25(OH)2D3. Calbindin-D28k is highly conserved in evolution. Calbindin-D9k, however, is present only in mammals. Evidence suggests that calbindin-D28k is involved in protection against apoptotic cell death by buffering calcium and by inhibiting caspase-3. Additional functions of calbindin include maintenance of intracellular calcium homeostasis and modulation of calcium influx.",

keywords = "1,25-dihydroxyvitamin D [1,25(OH)D], Apoptosis, Calbindin-D, Calbindin-D, Calcium, Intestine, Kidney, Knockout mice, Nervous tissue, Regulation, Vitamin D",

author = "Mady, {L. J.} and F. Haleem and S. Christakos",

year = "2013",

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T1 - Calcium-Buffering Proteins

T2 - Calbindin

AU - Mady, L. J.

AU - Haleem, F.

AU - Christakos, S.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - The calbindins, calbindin-D9k and calbindin-D28k, belong to a family of high-affinity calcium-binding proteins characterized by the EF hand structural motif. Calbindin was the first identified target of vitamin D action. It is now known that the calbindins are not exclusively regulated by vitamin D. They are present in many different tissues, serve different functions, and are regulated by factors other than 1,25(OH)2D3. Calbindin-D28k is highly conserved in evolution. Calbindin-D9k, however, is present only in mammals. Evidence suggests that calbindin-D28k is involved in protection against apoptotic cell death by buffering calcium and by inhibiting caspase-3. Additional functions of calbindin include maintenance of intracellular calcium homeostasis and modulation of calcium influx.

AB - The calbindins, calbindin-D9k and calbindin-D28k, belong to a family of high-affinity calcium-binding proteins characterized by the EF hand structural motif. Calbindin was the first identified target of vitamin D action. It is now known that the calbindins are not exclusively regulated by vitamin D. They are present in many different tissues, serve different functions, and are regulated by factors other than 1,25(OH)2D3. Calbindin-D28k is highly conserved in evolution. Calbindin-D9k, however, is present only in mammals. Evidence suggests that calbindin-D28k is involved in protection against apoptotic cell death by buffering calcium and by inhibiting caspase-3. Additional functions of calbindin include maintenance of intracellular calcium homeostasis and modulation of calcium influx.

KW - 1,25-dihydroxyvitamin D [1,25(OH)D]

KW - Apoptosis

KW - Calbindin-D

KW - Calcium

KW - Intestine

KW - Kidney

KW - Knockout mice

KW - Nervous tissue

KW - Regulation

KW - Vitamin D

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DO - 10.1016/B978-0-12-378630-2.00228-0

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AN - SCOPUS:85042746774

SN - 9780123786302

SP - 284

EP - 289

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc.

ER -

Calcium-Buffering Proteins: Calbindin

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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