Calcium signal transmission between ryanodine receptors and mitochondria in cardiac muscle

György Csordás, Andrew P. Thomas, György Hajnóczky

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Ryanodine receptor (RyR) mediated Ca2+ signals play a central role in excitation-contraction coupling in cardiac muscle. To support the rhythmic contractile activity there is a need for continuous tuning of cellular oxidative energy generation in the mitochondria to the actual work-load. Evidence has emerged that RyR-mediated cytosolic Ca2+ signals are efficiently transmitted to the mitochondria, providing a means for coupling cardiac muscle excitation to oxidative energy production, through activation of Ca2+ sensitive mitochondrial dehydrogenases. Recent data suggest that the Ca2+ signal transmission between RyR and mitochondria is dependent on local Ca2+ interactions between subdomains of sarcoplasmic reticulum (SR) and mitochondria. Here we give a short overview of the determinants and spatio-temporal organization of Ca2+ signal transmission between SR and mitochondria.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume11
Issue number7
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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