TY - JOUR
T1 - Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex
AU - Liauw, Jason
AU - Wu, Long Jun
AU - Zhuo, Min
PY - 2005/7
Y1 - 2005/7
N2 - Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while ACS subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.
AB - Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while ACS subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.
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U2 - 10.1152/jn.01205.2004
DO - 10.1152/jn.01205.2004
M3 - Article
C2 - 15985698
AN - SCOPUS:21544438755
SN - 0022-3077
VL - 94
SP - 878
EP - 882
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
IS - 1
ER -