Camptothecin delivery methods

A. Hatefi, B. Amsden

Research output: Contribution to journalReview article

139 Scopus citations


Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are required. Thus, this insolubility has restricted its clinical application. For these reasons, a number of water-soluble analogs have been synthesized and a number of different formulation approaches have been investigated. In this review, we examine each of these approaches and discuss their advantages and limitations.

Original languageEnglish (US)
Article number450749
Pages (from-to)1389-1399
Number of pages11
JournalPharmaceutical research
Issue number10
StatePublished - Jan 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


  • Antitumor activity
  • Camptothecin
  • Insolubility
  • Solubility

Fingerprint Dive into the research topics of 'Camptothecin delivery methods'. Together they form a unique fingerprint.

  • Cite this