Cancer Chemoprevention: What Have we Learned?

Chung S. Yang, Hong Wang, Vi Dan, Savanna San Filippo

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer is a major disease worldwide and different approaches are needed to reduce its risk. Previous laboratory studies suggested that cancer can be prevented by many naturally occurring and synthetic chemicals. In human cancer prevention studies, however, most of the successful examples are the repurposing of existing drugs, such as tamoxifen and aspirin. Epidemiological studies have established associations between certain dietary patterns or nutrient insufficiencies with elevated cancer risk. Laboratory research has also shown impressive results on the cancer preventive activities of constituents from food and beverages. However, such cancer preventive activities have not been demonstrated in many human intervention trials. This article reviews the advances in this field and discusses the reasons for the discrepancies between laboratory studies and human trials. Lessons learned for cancer prevention research in the past decades will be illustrated using studies with β-carotene, vitamin E, green tea polyphenols, tamoxifen, and aspirin as examples. In future studies, more interdisciplinary collaboration in the integration of laboratory and human studies are needed to advance the field of cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)409-422
Number of pages14
JournalCurrent Pharmacology Reports
Volume3
Issue number6
DOIs
StatePublished - Dec 1 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Pharmacology
  • Drug Discovery

Keywords

  • Aspirin
  • Cancer chemoprevention
  • Nutrients
  • Polyphenols
  • Tamoxifen
  • Tocopherols

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