Cancer in families with systemic sclerosis

L. I. Sakkas, D. F. Moore, N. C. Akritidis

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21 Scopus citations


In recent reports, researchers described an increased incidence of cancer in patients with systemic sclerosis (SScl). For this article, the authors investigated the frequencies of cancer in first-degree relatives of patients with SScl in a case-control family study. Information was obtained by personal interview of the probands. Fifty-three subjects with cancer were reported among 814 relatives of patients, compared with 17 subjects among 860 relatives of age- and sex-matched control subjects (age and sex adjusted odds ratio = 3.79, 95% confidence interval = 2.16-6.66, P < 0.001). Forty-six patients (27.7%) had one or more relatives with cancer, compared with 15 control subjects (9%). Within the limitations of the methods used, the researchers found an increased risk for cancer in first-degree relatives of patients with SScl. This suggests that a common genetic or environmental factor may be involved in the development of both cancer and SScl.

Original languageEnglish (US)
Pages (from-to)223-225
Number of pages3
JournalAmerican Journal of the Medical Sciences
Issue number6
StatePublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • Cancer
  • Families
  • Systemic sclerosis


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