Cancer prevention by different forms of tocopherols

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Many epidemiological studies have suggested that a low vitamin E nutritional status is associated with increased cancer risk. However, several recent large-scale human trials with high doses of α-tocopherol (α-T) have produced disappointing results. This points out the need for a better understanding of the biological activities of the different forms of tocopherols. Using a naturally occurring tocopherol mixture (γ-TmT) that is rich in γ-T, we demonstrated the inhibition of chemically induced lung, colon, and mammary cancer formation as well as the growth of xenograft tumors derived from human lung and prostate cancer cells. This broad anticancer activity of γ-TmT has been attributed mainly to the trapping of reactive oxygen and nitrogen species and inhibition of arachidonic acid metabolism. Activation of peroxisome proliferator-activated receptor γ (PPARγ) and the inhibition of estrogen signaling have also been observed in the inhibition of mammary cancer development. δ-T has been shown to be more active than γ-T in inhibiting the growth of human lung cancer cells in a xenograft tumor model and the development of aberrant crypt foci in azoxymethane-treated rats, whereas α-T is not effective in these models. The higher inhibitory activities of δ-T and γ-T (than α-T) are proposed to be due to their trapping of reactive nitrogen species and their capacity to generate side-chain degradation products, which retain the intact chromanol ring structure and could have cancer preventive activities.

Original languageEnglish (US)
Title of host publicationNatural Products in Cancer Prevention and Therapy
EditorsJohn Pezzuto, Nanjoo Suh
Pages21-34
Number of pages14
DOIs
StatePublished - Mar 18 2013

Publication series

NameTopics in Current Chemistry
Volume329
ISSN (Print)0340-1022

Fingerprint

Tocopherols
Reactive Nitrogen Species
Heterografts
Tumors
Cells
Azoxymethane
Enzyme inhibition
Peroxisome Proliferator-Activated Receptors
Bioactivity
Vitamin E
Arachidonic Acid
Metabolism
Rats
Reactive Oxygen Species
Estrogens
Chemical activation
Degradation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Keywords

  • Breast
  • Colon
  • Inhibition
  • Lung cancer
  • Prostate
  • Tocopherols
  • Vitamin E

Cite this

Yang, C., & Suh, N. (2013). Cancer prevention by different forms of tocopherols. In J. Pezzuto, & N. Suh (Eds.), Natural Products in Cancer Prevention and Therapy (pp. 21-34). (Topics in Current Chemistry; Vol. 329). https://doi.org/10.1007/128-2012-345
Yang, Chung ; Suh, Nanjoo. / Cancer prevention by different forms of tocopherols. Natural Products in Cancer Prevention and Therapy. editor / John Pezzuto ; Nanjoo Suh. 2013. pp. 21-34 (Topics in Current Chemistry).
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Yang, C & Suh, N 2013, Cancer prevention by different forms of tocopherols. in J Pezzuto & N Suh (eds), Natural Products in Cancer Prevention and Therapy. Topics in Current Chemistry, vol. 329, pp. 21-34. https://doi.org/10.1007/128-2012-345

Cancer prevention by different forms of tocopherols. / Yang, Chung; Suh, Nanjoo.

Natural Products in Cancer Prevention and Therapy. ed. / John Pezzuto; Nanjoo Suh. 2013. p. 21-34 (Topics in Current Chemistry; Vol. 329).

Research output: Chapter in Book/Report/Conference proceedingChapter

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N2 - Many epidemiological studies have suggested that a low vitamin E nutritional status is associated with increased cancer risk. However, several recent large-scale human trials with high doses of α-tocopherol (α-T) have produced disappointing results. This points out the need for a better understanding of the biological activities of the different forms of tocopherols. Using a naturally occurring tocopherol mixture (γ-TmT) that is rich in γ-T, we demonstrated the inhibition of chemically induced lung, colon, and mammary cancer formation as well as the growth of xenograft tumors derived from human lung and prostate cancer cells. This broad anticancer activity of γ-TmT has been attributed mainly to the trapping of reactive oxygen and nitrogen species and inhibition of arachidonic acid metabolism. Activation of peroxisome proliferator-activated receptor γ (PPARγ) and the inhibition of estrogen signaling have also been observed in the inhibition of mammary cancer development. δ-T has been shown to be more active than γ-T in inhibiting the growth of human lung cancer cells in a xenograft tumor model and the development of aberrant crypt foci in azoxymethane-treated rats, whereas α-T is not effective in these models. The higher inhibitory activities of δ-T and γ-T (than α-T) are proposed to be due to their trapping of reactive nitrogen species and their capacity to generate side-chain degradation products, which retain the intact chromanol ring structure and could have cancer preventive activities.

AB - Many epidemiological studies have suggested that a low vitamin E nutritional status is associated with increased cancer risk. However, several recent large-scale human trials with high doses of α-tocopherol (α-T) have produced disappointing results. This points out the need for a better understanding of the biological activities of the different forms of tocopherols. Using a naturally occurring tocopherol mixture (γ-TmT) that is rich in γ-T, we demonstrated the inhibition of chemically induced lung, colon, and mammary cancer formation as well as the growth of xenograft tumors derived from human lung and prostate cancer cells. This broad anticancer activity of γ-TmT has been attributed mainly to the trapping of reactive oxygen and nitrogen species and inhibition of arachidonic acid metabolism. Activation of peroxisome proliferator-activated receptor γ (PPARγ) and the inhibition of estrogen signaling have also been observed in the inhibition of mammary cancer development. δ-T has been shown to be more active than γ-T in inhibiting the growth of human lung cancer cells in a xenograft tumor model and the development of aberrant crypt foci in azoxymethane-treated rats, whereas α-T is not effective in these models. The higher inhibitory activities of δ-T and γ-T (than α-T) are proposed to be due to their trapping of reactive nitrogen species and their capacity to generate side-chain degradation products, which retain the intact chromanol ring structure and could have cancer preventive activities.

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Yang C, Suh N. Cancer prevention by different forms of tocopherols. In Pezzuto J, Suh N, editors, Natural Products in Cancer Prevention and Therapy. 2013. p. 21-34. (Topics in Current Chemistry). https://doi.org/10.1007/128-2012-345