Cancer prevention by tocopherols and tea polyphenols

Chung S. Yang, Guangxun Li, Zhihong Yang, Fei Guan, Amber Chen, Jihyeung Ju

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


Tocopherols (vitamin E) and tea polyphenols have been reported to have cancer preventive activities. Large-scale human trials with high doses of alpha-tocopherol, however, have produced disappointing results. This review presents data showing that - and -tocopherols inhibit colon, lung, mammary and prostate carcinogenesis in animal models, whereas -tocopherol is ineffective in animal and human studies. Possible mechanisms of action are discussed. A broad cancer preventive activity of green tea polyphenols has been demonstrated in animal models, and many mechanisms have been proposed. The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated and remains to be further investigated.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalCancer Letters
Issue number1
StatePublished - Jun 28 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


  • Cancer prevention
  • Green tea
  • Polyphenols
  • Tocopherols
  • Vitamin E


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