Candida albicans SRR1, a Putative Two-Component Response Regulator Gene, Is Required for Stress Adaptation, Morphogenesis, and Virulence

Chirayu Desai, John Mavrianos, Neeraj Chauhan

Research output: Contribution to journalArticle

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Abstract

We report here the identification and characterization of a previously uncharacterized, two-component response regulator gene (orf19.5843) from Candida albicans. Because of its apparent functions in stress adaptation, we have named this gene SRR1 (stress response regulator 1). Disruption of SRR1 causes defects in hyphal development, reduced resistance to stress, and severe virulence attenuation in the mouse model of disseminated candidiasis.

Original languageEnglish (US)
Pages (from-to)1370-1374
Number of pages5
JournalEukaryotic Cell
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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