Capture of rare cancer cells in microfluidic devices for treatment monitoring

Jose I. Varillas, Weian Sheng, Thomas J. George, Chen Liu, Z. Hugh Fan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report the capture and enumeration of circulating tumor cells (CTCs) in an antibody-coated polydimethylsiloxane (PDMS) microfluidic device. We studied the correlation between the number of CTCs, in peripheral blood, and the clinical result of pancreatic adenocarcinoma patients who went through a clinical trial using a drug cocktail. We found a direct correlation between the number of CTCs captured in the device and the change in tumor size measured by computer tomograms (CT scans).

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages576-578
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period10/26/1410/30/14

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Keywords

  • Circulating tumor cells
  • Microfluidics
  • Pancreatic cancer
  • Treatment monitoring

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