Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice

Zhengxue Liu, Tanima Kundu-Roy, Isao Matsuura, Guannan Wang, Yong Lin, You Rong Lou, Nicola J. Barnard, Xiao Fan Wang, Mou Tuan Huang, Nanjoo Suh, Fang Liu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.

Original languageEnglish (US)
Pages (from-to)64878-64885
Number of pages8
JournalOncotarget
Volume7
Issue number40
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology

Keywords

  • Breast cancer
  • Carcinogenesis
  • DMBA
  • Smad3
  • TGF-β

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