Cardiac amyloidosis in a patient with multiple myeloma: A case report and review of literature

David Sedaghat, Ramzan M. Zakir, Jin Choe, Marc Klapholz, Muhamed Saric

Research output: Contribution to journalArticle

17 Scopus citations


We report a case of a 52-year-old man with multiple myeloma and rapidly progressive heart failure who died unexpectedly from a probable arrhythmia. Postmortem examination revealed infiltrative amyloid cardiomyopathy, a rare cause of predominantly diastolic myocardial disease. Cardiac amyloidosis should be considered in any patient presenting with congestive heart failure, preserved systolic function, and a discrepancy between a low QRS voltage on electrocardiography and an apparent left ventricular hypertrophy on sonogram. The pattern of left ventricular diastolic dysfunction changes during the course of amyloidosis and the classically described restrictive physiology occurs only in advanced stages of the disease.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalJournal of Clinical Ultrasound
Issue number3
StatePublished - Mar 1 2009


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


  • Amyloidosis
  • Diastolic dysfunction
  • Multiple myeloma
  • Restrictive cardiomyopathy
  • Sonography

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