Cardiac parametric variations in post-ischemic myocardium

John K.J. Li; Ying Zhu; Kenneth Khaw; Joseph Kedem

Cardiac parametric variations in post-ischemic myocardium

John K.J. Li, Ying Zhu, Kenneth Khaw, Joseph Kedem

School of Engineering, Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Mechanisms governing post-ischemic ventricular function after episodes of acute myocardial ischemia are still unclear. We investigated this stunned myocardial function with a computer model in conjunction with animal experiments. A modified lumped cardiac muscle model was subjected to parametric changes similar to regionally recorded ventricular parameters. The model was perturbed by alterations in contractility and rates of activation and deactivation. Results show that the cardiac muscle model can mimic many of the physiological changes observed in a stunned myocardium.

Original language	English (US)
Pages (from-to)	3639-3641
Number of pages	3
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	26 V
State	Published - 2004
Event	Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Keywords

Cardiac muscle model
Myocardial ischemia and reperfusion

Cite this

@article{af0549f1710e4629a25f66180cbdb8fc,

title = "Cardiac parametric variations in post-ischemic myocardium",

abstract = "Mechanisms governing post-ischemic ventricular function after episodes of acute myocardial ischemia are still unclear. We investigated this stunned myocardial function with a computer model in conjunction with animal experiments. A modified lumped cardiac muscle model was subjected to parametric changes similar to regionally recorded ventricular parameters. The model was perturbed by alterations in contractility and rates of activation and deactivation. Results show that the cardiac muscle model can mimic many of the physiological changes observed in a stunned myocardium.",

keywords = "Cardiac muscle model, Myocardial ischemia and reperfusion",

author = "Li, {John K.J.} and Ying Zhu and Kenneth Khaw and Joseph Kedem",

year = "2004",

language = "English (US)",

volume = "26 V",

pages = "3639--3641",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 ; Conference date: 01-09-2004 Through 05-09-2004",

}

TY - JOUR

T1 - Cardiac parametric variations in post-ischemic myocardium

AU - Li, John K.J.

AU - Zhu, Ying

AU - Khaw, Kenneth

AU - Kedem, Joseph

PY - 2004

Y1 - 2004

N2 - Mechanisms governing post-ischemic ventricular function after episodes of acute myocardial ischemia are still unclear. We investigated this stunned myocardial function with a computer model in conjunction with animal experiments. A modified lumped cardiac muscle model was subjected to parametric changes similar to regionally recorded ventricular parameters. The model was perturbed by alterations in contractility and rates of activation and deactivation. Results show that the cardiac muscle model can mimic many of the physiological changes observed in a stunned myocardium.

AB - Mechanisms governing post-ischemic ventricular function after episodes of acute myocardial ischemia are still unclear. We investigated this stunned myocardial function with a computer model in conjunction with animal experiments. A modified lumped cardiac muscle model was subjected to parametric changes similar to regionally recorded ventricular parameters. The model was perturbed by alterations in contractility and rates of activation and deactivation. Results show that the cardiac muscle model can mimic many of the physiological changes observed in a stunned myocardium.

KW - Cardiac muscle model

KW - Myocardial ischemia and reperfusion

UR - http://www.scopus.com/inward/record.url?scp=11144276065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144276065&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:11144276065

SN - 0589-1019

VL - 26 V

SP - 3639

EP - 3641

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004

Y2 - 1 September 2004 through 5 September 2004

ER -

Cardiac parametric variations in post-ischemic myocardium

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Other files and links

Fingerprint

Cite this