Cardiac sodium channel structure and function

Sidney A. Cohen, Robert Barchi

Research output: Contribution to journalShort survey

16 Citations (Scopus)

Abstract

The upstroke of the action potential in heart cells, as in nerve and skeletal muscle cells, is due to the movement of sodium ions through ion-selective channels in the surface membrane. Voltage-dependent sodium channels in the heart, while sharing many common electrophysiologic characteristics with sodium channels in nerve and skeletal muscle, are distinctive in that they also contribute current to the plateau phase of the action potential and have unique sensitivities to channel-active toxins and drugs, most notably the local anesthetic-type antiarrhythmic agents. With the recent cloning and functional expression of the rat and human cardiac sodium channel genes, we are now in a position to understand better the molecular mechanisms responsible for the unique characteristics of sodium channels in the heart.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1992

Fingerprint

Sodium Channels
Action Potentials
Skeletal Muscle
Local Anesthetics
Ion Channels
Muscle Cells
Anesthetics
Organism Cloning
Sodium
Ions
Membranes
Pharmaceutical Preparations
Genes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "The upstroke of the action potential in heart cells, as in nerve and skeletal muscle cells, is due to the movement of sodium ions through ion-selective channels in the surface membrane. Voltage-dependent sodium channels in the heart, while sharing many common electrophysiologic characteristics with sodium channels in nerve and skeletal muscle, are distinctive in that they also contribute current to the plateau phase of the action potential and have unique sensitivities to channel-active toxins and drugs, most notably the local anesthetic-type antiarrhythmic agents. With the recent cloning and functional expression of the rat and human cardiac sodium channel genes, we are now in a position to understand better the molecular mechanisms responsible for the unique characteristics of sodium channels in the heart.",
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Cardiac sodium channel structure and function. / Cohen, Sidney A.; Barchi, Robert.

In: Trends in Cardiovascular Medicine, Vol. 2, No. 4, 01.01.1992, p. 133-140.

Research output: Contribution to journalShort survey

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T1 - Cardiac sodium channel structure and function

AU - Cohen, Sidney A.

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N2 - The upstroke of the action potential in heart cells, as in nerve and skeletal muscle cells, is due to the movement of sodium ions through ion-selective channels in the surface membrane. Voltage-dependent sodium channels in the heart, while sharing many common electrophysiologic characteristics with sodium channels in nerve and skeletal muscle, are distinctive in that they also contribute current to the plateau phase of the action potential and have unique sensitivities to channel-active toxins and drugs, most notably the local anesthetic-type antiarrhythmic agents. With the recent cloning and functional expression of the rat and human cardiac sodium channel genes, we are now in a position to understand better the molecular mechanisms responsible for the unique characteristics of sodium channels in the heart.

AB - The upstroke of the action potential in heart cells, as in nerve and skeletal muscle cells, is due to the movement of sodium ions through ion-selective channels in the surface membrane. Voltage-dependent sodium channels in the heart, while sharing many common electrophysiologic characteristics with sodium channels in nerve and skeletal muscle, are distinctive in that they also contribute current to the plateau phase of the action potential and have unique sensitivities to channel-active toxins and drugs, most notably the local anesthetic-type antiarrhythmic agents. With the recent cloning and functional expression of the rat and human cardiac sodium channel genes, we are now in a position to understand better the molecular mechanisms responsible for the unique characteristics of sodium channels in the heart.

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