Cardiovascular outcomes after preeclampsia or eclampsia complicated by myocardial infarction or stroke

Mary Downes Gastrich, Sampada K. Gandhi, John Pantazopoulos, Edith A. Zang, Nora M. Cosgrove, Javier Cabrera, Jeanine E. Sedjro, Gloria Bachmann, John Kostis

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE: To assess the relationship between preeclampsia or eclampsia and stroke, myocardial infarction (MI), subsequent cardiovascular outcomes, and long-term survival. METHODS: Using the Myocardial Infarction Data Acquisition System in New Jersey (1994-2009), we analyzed cardiovascular outcomes in women with and without preeclampsia or eclampsia and a first MI or stroke but with a hospitalization for a first MI or stroke (analysis 1: MI case group, n=57; MI control group, n=155; stroke case group, n=132; stroke control group, n=379). We also compared these outcomes in women with preeclampsia or eclampsia and a first MI or stroke during pregnancy with women with preeclampsia or eclampsia without MI or stroke during pregnancy (analysis 2: MI case group, n=23; MI control group, n=67; stroke case group, n=90; stroke control group, n=263). A subsequent occurrence of MI, stroke, and cardiovascular death, as well as a combined cardiovascular outcome, was ascertained. RESULTS: In analysis 1, women with preeclampsia or eclampsia were at significantly lower risk for combined cardiovascular outcome with all deaths (frequency of outcome 16.7%) and with cardiovascular deaths (10.6%) compared with women without preeclampsia or eclampsia after a first stroke (33.8% and 23.5%, respectively). In analysis 2, women with preeclampsia or eclampsia and a first stroke during admission were at significantly higher risk of all death (11.1%) and the combined cardiovascular outcome with all deaths (11.1%) compared with women with preeclampsia or eclampsia without a stroke (1.9% and 2.7%, respectively) during that admission. CONCLUSION: Our study indicates that preeclampsia or eclampsia not complicated by MI or stroke during pregnancy may not confer a very high risk for subsequent MI and stroke in up to 16 years of follow-up. Our data suggest that other known risk factors put women at greater risk for stroke than preeclampsia or eclampsia complicated by a stroke.

Original languageEnglish (US)
Pages (from-to)823-831
Number of pages9
JournalObstetrics and gynecology
Volume120
Issue number4
DOIs
StatePublished - Oct 1 2012

Fingerprint

Eclampsia
Pre-Eclampsia
Stroke
Myocardial Infarction
Control Groups
Pregnancy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Gastrich, Mary Downes ; Gandhi, Sampada K. ; Pantazopoulos, John ; Zang, Edith A. ; Cosgrove, Nora M. ; Cabrera, Javier ; Sedjro, Jeanine E. ; Bachmann, Gloria ; Kostis, John. / Cardiovascular outcomes after preeclampsia or eclampsia complicated by myocardial infarction or stroke. In: Obstetrics and gynecology. 2012 ; Vol. 120, No. 4. pp. 823-831.
@article{648d835977b647d7a81d40582e9b973f,
title = "Cardiovascular outcomes after preeclampsia or eclampsia complicated by myocardial infarction or stroke",
abstract = "OBJECTIVE: To assess the relationship between preeclampsia or eclampsia and stroke, myocardial infarction (MI), subsequent cardiovascular outcomes, and long-term survival. METHODS: Using the Myocardial Infarction Data Acquisition System in New Jersey (1994-2009), we analyzed cardiovascular outcomes in women with and without preeclampsia or eclampsia and a first MI or stroke but with a hospitalization for a first MI or stroke (analysis 1: MI case group, n=57; MI control group, n=155; stroke case group, n=132; stroke control group, n=379). We also compared these outcomes in women with preeclampsia or eclampsia and a first MI or stroke during pregnancy with women with preeclampsia or eclampsia without MI or stroke during pregnancy (analysis 2: MI case group, n=23; MI control group, n=67; stroke case group, n=90; stroke control group, n=263). A subsequent occurrence of MI, stroke, and cardiovascular death, as well as a combined cardiovascular outcome, was ascertained. RESULTS: In analysis 1, women with preeclampsia or eclampsia were at significantly lower risk for combined cardiovascular outcome with all deaths (frequency of outcome 16.7{\%}) and with cardiovascular deaths (10.6{\%}) compared with women without preeclampsia or eclampsia after a first stroke (33.8{\%} and 23.5{\%}, respectively). In analysis 2, women with preeclampsia or eclampsia and a first stroke during admission were at significantly higher risk of all death (11.1{\%}) and the combined cardiovascular outcome with all deaths (11.1{\%}) compared with women with preeclampsia or eclampsia without a stroke (1.9{\%} and 2.7{\%}, respectively) during that admission. CONCLUSION: Our study indicates that preeclampsia or eclampsia not complicated by MI or stroke during pregnancy may not confer a very high risk for subsequent MI and stroke in up to 16 years of follow-up. Our data suggest that other known risk factors put women at greater risk for stroke than preeclampsia or eclampsia complicated by a stroke.",
author = "Gastrich, {Mary Downes} and Gandhi, {Sampada K.} and John Pantazopoulos and Zang, {Edith A.} and Cosgrove, {Nora M.} and Javier Cabrera and Sedjro, {Jeanine E.} and Gloria Bachmann and John Kostis",
year = "2012",
month = "10",
day = "1",
doi = "10.1097/AOG.0b013e31826ae78a",
language = "English (US)",
volume = "120",
pages = "823--831",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Cardiovascular outcomes after preeclampsia or eclampsia complicated by myocardial infarction or stroke. / Gastrich, Mary Downes; Gandhi, Sampada K.; Pantazopoulos, John; Zang, Edith A.; Cosgrove, Nora M.; Cabrera, Javier; Sedjro, Jeanine E.; Bachmann, Gloria; Kostis, John.

In: Obstetrics and gynecology, Vol. 120, No. 4, 01.10.2012, p. 823-831.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiovascular outcomes after preeclampsia or eclampsia complicated by myocardial infarction or stroke

AU - Gastrich, Mary Downes

AU - Gandhi, Sampada K.

AU - Pantazopoulos, John

AU - Zang, Edith A.

AU - Cosgrove, Nora M.

AU - Cabrera, Javier

AU - Sedjro, Jeanine E.

AU - Bachmann, Gloria

AU - Kostis, John

PY - 2012/10/1

Y1 - 2012/10/1

N2 - OBJECTIVE: To assess the relationship between preeclampsia or eclampsia and stroke, myocardial infarction (MI), subsequent cardiovascular outcomes, and long-term survival. METHODS: Using the Myocardial Infarction Data Acquisition System in New Jersey (1994-2009), we analyzed cardiovascular outcomes in women with and without preeclampsia or eclampsia and a first MI or stroke but with a hospitalization for a first MI or stroke (analysis 1: MI case group, n=57; MI control group, n=155; stroke case group, n=132; stroke control group, n=379). We also compared these outcomes in women with preeclampsia or eclampsia and a first MI or stroke during pregnancy with women with preeclampsia or eclampsia without MI or stroke during pregnancy (analysis 2: MI case group, n=23; MI control group, n=67; stroke case group, n=90; stroke control group, n=263). A subsequent occurrence of MI, stroke, and cardiovascular death, as well as a combined cardiovascular outcome, was ascertained. RESULTS: In analysis 1, women with preeclampsia or eclampsia were at significantly lower risk for combined cardiovascular outcome with all deaths (frequency of outcome 16.7%) and with cardiovascular deaths (10.6%) compared with women without preeclampsia or eclampsia after a first stroke (33.8% and 23.5%, respectively). In analysis 2, women with preeclampsia or eclampsia and a first stroke during admission were at significantly higher risk of all death (11.1%) and the combined cardiovascular outcome with all deaths (11.1%) compared with women with preeclampsia or eclampsia without a stroke (1.9% and 2.7%, respectively) during that admission. CONCLUSION: Our study indicates that preeclampsia or eclampsia not complicated by MI or stroke during pregnancy may not confer a very high risk for subsequent MI and stroke in up to 16 years of follow-up. Our data suggest that other known risk factors put women at greater risk for stroke than preeclampsia or eclampsia complicated by a stroke.

AB - OBJECTIVE: To assess the relationship between preeclampsia or eclampsia and stroke, myocardial infarction (MI), subsequent cardiovascular outcomes, and long-term survival. METHODS: Using the Myocardial Infarction Data Acquisition System in New Jersey (1994-2009), we analyzed cardiovascular outcomes in women with and without preeclampsia or eclampsia and a first MI or stroke but with a hospitalization for a first MI or stroke (analysis 1: MI case group, n=57; MI control group, n=155; stroke case group, n=132; stroke control group, n=379). We also compared these outcomes in women with preeclampsia or eclampsia and a first MI or stroke during pregnancy with women with preeclampsia or eclampsia without MI or stroke during pregnancy (analysis 2: MI case group, n=23; MI control group, n=67; stroke case group, n=90; stroke control group, n=263). A subsequent occurrence of MI, stroke, and cardiovascular death, as well as a combined cardiovascular outcome, was ascertained. RESULTS: In analysis 1, women with preeclampsia or eclampsia were at significantly lower risk for combined cardiovascular outcome with all deaths (frequency of outcome 16.7%) and with cardiovascular deaths (10.6%) compared with women without preeclampsia or eclampsia after a first stroke (33.8% and 23.5%, respectively). In analysis 2, women with preeclampsia or eclampsia and a first stroke during admission were at significantly higher risk of all death (11.1%) and the combined cardiovascular outcome with all deaths (11.1%) compared with women with preeclampsia or eclampsia without a stroke (1.9% and 2.7%, respectively) during that admission. CONCLUSION: Our study indicates that preeclampsia or eclampsia not complicated by MI or stroke during pregnancy may not confer a very high risk for subsequent MI and stroke in up to 16 years of follow-up. Our data suggest that other known risk factors put women at greater risk for stroke than preeclampsia or eclampsia complicated by a stroke.

UR - http://www.scopus.com/inward/record.url?scp=84866914496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866914496&partnerID=8YFLogxK

U2 - 10.1097/AOG.0b013e31826ae78a

DO - 10.1097/AOG.0b013e31826ae78a

M3 - Article

C2 - 22996100

AN - SCOPUS:84866914496

VL - 120

SP - 823

EP - 831

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 4

ER -