Carotenoid status of pregnant women with and without HIV infection in Malawi

Y. Lan, N. Kumwenda, T. E. Taha, J. D. Chiphangwi, P. G. Miotti, L. Mtimavalye, R. Broadhead, L. Van Der Hoeven, D. R. Hoover, R. D. Semba

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: To characterise the major plasma carotenoids in pregnant women with and without HIV infection attending antenatal clinic in Blantyre, Malawi. Design: A cross sectional study. Setting: Antenatal clinic of Queen Elizabeth Central Hospital, Blantyre, Malawi. Subjects: Nine hundred women (697 HIV-positive and 203 HIV-negative women) in their second trimester of pregancy. Main outcome measures: Plasma carotenoid levels as related to HIV status and level of disease progression. Results: There were no significant differences in plasma carotenoid levels between HIV-positive and HIV-negative women. Median (25th, 75th percentiles) plasma levels of carotenoids for all women in the study were α-carotene, 0.040 (0.23, 0.071) μmol/L; β-carotene, 0.350 (0.192, 0.595) μmol/L; β-cryptoxanthin, 0.050 (0.029, 0.091) μmol/L; lutein/zeaxanthin 0.646 (0.426, 0.976) μmol/L; lycopene, 0.088 (0.055, 0.138) μmol/L, and total carotenoids 1.321 (0.884, 1.874) μmol/L. Mothers had higher mean plasma concentrations of α-carotene (p < 0.04), β-carotene (p < 0.0001), lutein/zeaxanthin (p < 0.0001), and total carotenoids (p < 0.0001) in the wet season than the dry season. No seasonality was observed for β-cryptoxanthin, lycopene, or retinol. Conclusion: This study suggests that pregnant women with and without HIV infection in Blantyre, Malawi have relatively low plasma carotenoid levels and poor dietary intake of provitamin A carotenoids.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalEast African Medical Journal
Volume76
Issue number3
StatePublished - Mar 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Carotenoid status of pregnant women with and without HIV infection in Malawi'. Together they form a unique fingerprint.

Cite this