Causal pathways between impulsiveness, cocaine use consequences, and depression

Jamey J. Lister, David M. Ledgerwood, Leslie H. Lundahl, Mark K. Greenwald

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Aims: The present study examined whether lifetime cocaine use consequences mediate the relationship between trait impulsiveness and current depression symptoms among regular cocaine users. Methods: Regular cocaine users (. N=. 108) were assessed using: Barratt Impulsiveness Scale subscales (non-planning, attentional, motor sub-scales) to measure trait impulsiveness; a standardized Drug History and Use Questionnaire to measure cocaine use and related consequences; and Beck Depression Inventory to measure current depression symptoms. Results: All impulsiveness subscales were positively associated with an earlier age of first cocaine use, a higher degree of current depression symptoms and a greater number of lifetime cocaine use consequences. In three separate simple mediation tests, lifetime cocaine use consequences partially mediated the relationship between each of the impulsiveness subscales (non-planning: R2=.42; attentional: R2=.40; motor: R2=.24) and current depression symptoms. Separate moderated mediation analyses failed to demonstrate an interaction between lifetime cocaine use and cocaine-related consequences predicting depression symptoms for the mediation models. Conclusions: Cocaine-related consequences function in a more nuanced manner than just an outcome of impulsiveness or cocaine use, but as a pathway between trait impulsiveness and current depression symptoms.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalAddictive Behaviors
StatePublished - Feb 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Toxicology
  • Psychiatry and Mental health


  • Cocaine
  • Cocaine use consequences
  • Depression
  • Impulsiveness
  • Pathways


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