CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

Yosuke Kumamoto, Joao Paulo G. Camporez, Michael J. Jurczak, Marya Shanabrough, Tamas Horvath, Gerald I. Shulman, Akiko Iwasaki

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b+CD11c+MHCII+ MNPs in multiple organs including adipose tissues. Depleting CD301b+ MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) α, a multifunctional cytokine produced by MNPs. Reconstituting RELMα in CD301b+ MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b+ MNPs play crucial roles in maintaining glucose metabolism and net energy balance.

Original languageEnglish (US)
Pages (from-to)583-596
Number of pages14
JournalImmunity
Volume45
Issue number3
DOIs
StatePublished - Sep 20 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Keywords

  • adipose tissue macrophage
  • alternatively activated macrophage
  • glucose metabolism

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