CD3+CD8+ cell levels as predictors of transmission in human immunodeficiency virus-infected couples: A report from the heterosexual HIV transmission study

Thomas N. Denny, Joan H. Skurnick, Paul Palumbo, George Perez, Raymond Monel, Richard Stephens, Cheryl A. Kennedy, Donald B. Louria

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective: The goal of this study was to identify in human immunodeficiency virus (HIV)-infected individuals immunologic markers that correlated with transmission of HIV by heterosexual contact. Methods: In a case-control comparison of couples, immunologic and viral parameters were evaluated in 343 HIV-positive individuals who were members of 67 HIV- seroconcordant couples (both partners HIV positive) and 211 HIV serodiscordant couples (one positive, one negative). Results: The most striking immunologic finding was the increased numbers of CD3+CD8+ cells found in the index member of discordant couples as compared to the index member of the concordant couples. Differences in CD3+CD8+ levels persisted after adjustment for stage of disease and CD3+CD4+ count. This increase in the number of CD3+CD8+ cells was accompanied by a concomitant decrease in the amount of viral replication measured by both HIV culture endpoint and quantitative RNA polymerase chain reaction (PCR). Conclusion: Data presented here further support the role of CD3+CD8+ cells in suppressing or controlling vital activity, although a causal role based on case-control data must be advanced cautiously. This in vivo biologic function may help prevent or lower the risk of HIV transmission.

Original languageEnglish (US)
Pages (from-to)186-192
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume2
Issue number4
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Keywords

  • CD3+CD8+ cells
  • Concordant
  • Discordant
  • HIV-positive

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