Cell Adhesion, Cellular Tension, and Cell Cycle Control

Eric A. Klein, Yuval Yung, Paola Castagnino, Devashish Kothapalli, Richard K. Assoian

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Scopus citations


Cooperative signaling between growth factor receptor tyrosine kinases, integrins, and the actin cytoskeleton is required for activation of the G1-phase cyclin-dependent kinases and progression through G1-phase. Increasing evidence suggests that there is cell type specificity in these cooperative interactions and that the compliance of the underlying substratum can strongly affect adhesion-dependent signaling to the cell cycle. This chapter reviews our current methods for studying how cell type specificity and changes in substratum compliance can contribute to G1-phase cell cycle control. We also describe several of our current analytical procedures.

Original languageEnglish (US)
Title of host publicationIntegrins
EditorsDavid Cheresh
Number of pages21
StatePublished - 2007
Externally publishedYes

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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