Cell-cycle checkpoint kinases: Checking in on the cell cycle

Research output: Contribution to journalReview article

113 Scopus citations


In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.

Original languageEnglish (US)
Pages (from-to)697-704
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Cell Biology

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