TY - JOUR
T1 - Cell-cycle checkpoint kinases
T2 - Checking in on the cell cycle
AU - Walworth, Nancy C.
N1 - Funding Information:
I thank Thanos Halazonetis, Kim McKim, Matthew O'Connell and Michael Shen for helpful discussions and suggestions on the manuscript. Research in my laboratory is supported by the National Institutes of Health grant (GM53194) and the Sinsheimer Foundation.
PY - 2000
Y1 - 2000
N2 - In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.
AB - In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.
UR - http://www.scopus.com/inward/record.url?scp=0033710224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033710224&partnerID=8YFLogxK
U2 - 10.1016/S0955-0674(00)00154-X
DO - 10.1016/S0955-0674(00)00154-X
M3 - Review article
C2 - 11063934
AN - SCOPUS:0033710224
SN - 0955-0674
VL - 12
SP - 697
EP - 704
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -