Cell migration on cell-internalizable ligand microdepots: A phenomenological model

Jane S. Tjia; Prabhas V. Moghe

doi:10.1114/1.1492814

Cell migration on cell-internalizable ligand microdepots: A phenomenological model

Jane S. Tjia, Prabhas V. Moghe

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The dynamics of cell-ligand associated microdepots (LAM) interactions, through a phenomenological model to examine the differential effects of LAM-cell binding and LAM internalization within the cells were studied. The model was solved to yield rates of LAM binding and internalization at various LAM substrate densities. It was shown that the rate of cell migration can be governed by rate of cellular sampling LAMs, given by differential rates of LAM binding and internalization.

Original language	English (US)
Pages (from-to)	851-866
Number of pages	16
Journal	Annals of Biomedical Engineering
Volume	30
Issue number	6
DOIs	https://doi.org/10.1114/1.1492814
State	Published - 2002

All Science Journal Classification (ASJC) codes

Biomedical Engineering

Keywords

Cell migration
Ligand microengineering
Microparticles
Nanoparticles
Receptor-mediated cell endocytosis

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10.1114/1.1492814

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title = "Cell migration on cell-internalizable ligand microdepots: A phenomenological model",

abstract = "The dynamics of cell-ligand associated microdepots (LAM) interactions, through a phenomenological model to examine the differential effects of LAM-cell binding and LAM internalization within the cells were studied. The model was solved to yield rates of LAM binding and internalization at various LAM substrate densities. It was shown that the rate of cell migration can be governed by rate of cellular sampling LAMs, given by differential rates of LAM binding and internalization.",

keywords = "Cell migration, Ligand microengineering, Microparticles, Nanoparticles, Receptor-mediated cell endocytosis",

author = "Tjia, {Jane S.} and Moghe, {Prabhas V.}",

note = "Funding Information: This study was supported by Johnson & Johnson Discovery Award, ConvaTec Young Professor Award, and Hoechst Celanese Innovative Research Award to P. Moghe. The authors would like to thank Howard Salis, a NJ Center for Biomaterials Summer Fellow, and Patrick Hossler for their help with image analysis. One of the authors (J.S.T.) was partially supported by the Rutgers– UMDNJ National Institutes of Health Biotechnology Training Grant, and the Rutgers University Louis Bevier Fellowship.",

year = "2002",

doi = "10.1114/1.1492814",

language = "English (US)",

volume = "30",

pages = "851--866",

journal = "Annals of Biomedical Engineering",

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T1 - Cell migration on cell-internalizable ligand microdepots

T2 - A phenomenological model

AU - Tjia, Jane S.

AU - Moghe, Prabhas V.

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PY - 2002

Y1 - 2002

N2 - The dynamics of cell-ligand associated microdepots (LAM) interactions, through a phenomenological model to examine the differential effects of LAM-cell binding and LAM internalization within the cells were studied. The model was solved to yield rates of LAM binding and internalization at various LAM substrate densities. It was shown that the rate of cell migration can be governed by rate of cellular sampling LAMs, given by differential rates of LAM binding and internalization.

AB - The dynamics of cell-ligand associated microdepots (LAM) interactions, through a phenomenological model to examine the differential effects of LAM-cell binding and LAM internalization within the cells were studied. The model was solved to yield rates of LAM binding and internalization at various LAM substrate densities. It was shown that the rate of cell migration can be governed by rate of cellular sampling LAMs, given by differential rates of LAM binding and internalization.

KW - Cell migration

KW - Ligand microengineering

KW - Microparticles

KW - Nanoparticles

KW - Receptor-mediated cell endocytosis

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EP - 866

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - 6

ER -

Cell migration on cell-internalizable ligand microdepots: A phenomenological model

Abstract

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