Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells

J. D. Jamieson, D. E. Ingber, Virgil Muresan, B. E. Hull, M. P. Sarras, M. ‐F Maylié‐Pfenninger, V. Iwanij

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Acinar, centroacinar, and endocrine cells of the adult rat pancreas each exhibit distinctive cell‐surface glycoconjugate patterns as detected by binding of a battery of lectin‐ferritin conjugates. Acquisition of these unique glycoconjugate patterns appears to be developmentally regulated, as studies on embryonic rat pancreases at days 15, 17, and 19 of gestation indicate. Further, the three cell types appear to arise from a common stem cell(s) with surface glycoconjugate properties similar to those of the adult centroacinar cell. Studies on the cell‐surface properties of a rat acinar cell tumor20 indicate that the neoplastic acinar cells are likely to be arrested at a developmental stage equivalent to acinar cells of the day 19 embryonic pancreas and are characterized by absence of detectable basal lamina. We hypothesize that pancreatic cancers may arise from the equivalent of the undifferentiated embryonic stem cell(s) and that the morphologic features of the tumor depend on the extent of cell differentiation, including expression of cell‐surface glycoproteins and extracellular matrix, prior to neoplastic proliferation.

Original languageEnglish (US)
Pages (from-to)1516-1525
Number of pages10
JournalCancer
Volume47
Issue number6 S
DOIs
StatePublished - Jan 1 1981

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Surface Properties
Acinar Cells
Glycoconjugates
Pancreas
Endocrine Cells
Embryonic Stem Cells
Pancreatic Neoplasms
Basement Membrane
Extracellular Matrix
Cell Differentiation
Glycoproteins
Stem Cells
Pregnancy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Jamieson, J. D., Ingber, D. E., Muresan, V., Hull, B. E., Sarras, M. P., Maylié‐Pfenninger, M. F., & Iwanij, V. (1981). Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells. Cancer, 47(6 S), 1516-1525. https://doi.org/10.1002/1097-0142(19810315)47:6+<1516::AID-CNCR2820471413>3.0.CO;2-9
Jamieson, J. D. ; Ingber, D. E. ; Muresan, Virgil ; Hull, B. E. ; Sarras, M. P. ; Maylié‐Pfenninger, M. ‐F ; Iwanij, V. / Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells. In: Cancer. 1981 ; Vol. 47, No. 6 S. pp. 1516-1525.
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Jamieson, JD, Ingber, DE, Muresan, V, Hull, BE, Sarras, MP, Maylié‐Pfenninger, MF & Iwanij, V 1981, 'Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells', Cancer, vol. 47, no. 6 S, pp. 1516-1525. https://doi.org/10.1002/1097-0142(19810315)47:6+<1516::AID-CNCR2820471413>3.0.CO;2-9

Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells. / Jamieson, J. D.; Ingber, D. E.; Muresan, Virgil; Hull, B. E.; Sarras, M. P.; Maylié‐Pfenninger, M. ‐F; Iwanij, V.

In: Cancer, Vol. 47, No. 6 S, 01.01.1981, p. 1516-1525.

Research output: Contribution to journalArticle

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AU - Iwanij, V.

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