Cellular and subcellular localization of lets protein in the nervous system

In the nervous system of several mammalian and submammalian species, LETS protein is detectable on endothelial cells, choroid epithelial cells, fibroblasts and leptomeningeal cells. On endothelial cells LETS is present at the cell surface facing the blood vessel lumen, but not the glia limitans nor its basal lamina. Choroid epithelial cells do not carry LETS at their apices protruding into the ventricle, but are antigen-positive at their basal ends, in basal lamina and plasma membrane. Fibroblasts in the leptomeninges express LETS at their cell surface only, whereas pial and arachnoidal cells contain the protein also intracellularly. Neither glial nor neuronal cells express LETS protein. This pattern of LETS localization in nervous tissue was observed for adult and developing (embryonal day 9 onwards) animals of two species: mouse and chicken.