Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang; Xiaoxin Chen; Manisha Bajpai; Amit Verma; Kiron M. Das; Rhonda F. Souza; Katherine S. Garman; Claire L. Donohoe; Naoimh J. O'Farrell; John V. Reynolds; Katerina Dvorak

doi:10.1111/nyas.12249

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang, Xiaoxin Chen, Manisha Bajpai, Amit Verma, Kiron M. Das, Rhonda F. Souza, Katherine S. Garman, Claire L. Donohoe, Naoimh J. O'Farrell, John V. Reynolds, Katerina Dvorak

Robert Wood Johnson Medical School (RWJMS), Medicine, Division of Gastroenterology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

Original language	English (US)
Pages (from-to)	187-199
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	1300
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12249
State	Published - Oct 2013

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Keywords

Autophagy
Barrett's esophagus
DNA methylation
Esophageal adenocarcinoma
Obesity

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10.1111/nyas.12249

Cite this

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abstract = "This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.",

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AU - Chen, Xiaoxin

AU - Bajpai, Manisha

AU - Verma, Amit

AU - Das, Kiron M.

AU - Souza, Rhonda F.

AU - Garman, Katherine S.

AU - Donohoe, Claire L.

AU - O'Farrell, Naoimh J.

AU - Reynolds, John V.

AU - Dvorak, Katerina

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Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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