Cellular stress responses and metabolic reprogramming in cancer progression and dormancy

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7 Scopus citations


Recurrent disease after prolonged cancer dormancy is a major cause of cancer associated mortality, yet many of the mechanisms that are engaged to initiate dormancy as well as later recurrence remain incompletely understood. It is known that cancer cells initiate adaptation mechanisms to adapt tightly regulated cellular processes to non-optimal growth environments; Recent investigations have begun to elucidate the contribution of these mechanisms to malignant progression, with intriguing studies now defining cellular stress as a key contributor to the development and maintenance of cancer dormancy. This review will focus on our current understanding of stress responses facilitating malignant cell adaptation and metabolic reprogramming to establish cancer dormancy.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalSeminars in Cancer Biology
StatePublished - Jan 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research


  • Cancer dormancy
  • Cancer recurrence
  • Endoplasmic reticulum stress
  • Metabolism
  • Oxidative stress


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