The etiology and pathogenesis of parkinsonian motor fluctations have been the focus of substantial investigative attention. Potential factors interfering with the effect of levodopa can be divided into two categories: extracerebral (or peripheral) mechanisms primarily related to the drug itself and its pharmacokinetics, and cerebral (or central) mechanisms related to the interaction of levodopa with neural elements.
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Pharmacology (medical)