Central mechanisms and levodopa response fluctuations in Parkinson's disease

M. M. Mouradian, T. N. Chase

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


The etiology and pathogenesis of parkinsonian motor fluctations have been the focus of substantial investigative attention. Potential factors interfering with the effect of levodopa can be divided into two categories: extracerebral (or peripheral) mechanisms primarily related to the drug itself and its pharmacokinetics, and cerebral (or central) mechanisms related to the interaction of levodopa with neural elements.

Original languageEnglish (US)
Pages (from-to)378-385
Number of pages8
JournalClinical Neuropharmacology
Issue number4
StatePublished - 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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