The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. The purpose of this supplement is to provide a concise reference of the newly available literature to support the existing information regarding the known adverse effects of commonly prescribed medications or abused drugs. The information covers peer-reviewed publications from January 2018 to December 2018. This review focused on CNS stimulants and drugs that suppress appetite. It covers amphetamines (including lisdexamfetamine, methamphetamine and 3,4-methylenedioxymetamphetamine), methylphenidate, atomoxetine, modafinil and armodafinil, suvorexant, methylxanthines (caffeine), monotherapies and combinational therapies that suppress appetite (phentermine, phentermine/topiramate) and medications used in Alzheimer's disease and cognitive decline (rivastigmine, donepezil and memantine).