Central resetting of baroreflex in the spontaneously hypertensive rat

Eulogio R. Gonzalez, Abbott J. Krieger, Hreday N. Sapru

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The role of central nervous system in the resetting of baroreflex was investigated in 5- month-old spontaneously hypertensive rats (SHR) of Okamoto strain. Age-matched Wistar-Kyoto (WKY) rats were used as normotensive controls. The aortic nerves, which in the rat, contain few or no chemoreceptor fibers, were stimulated electrically using a wide range of stimulus frequencies. The depressor responses (expressed as percent decrease in blood pressure as compared to its blood pressure value prior to aortic nerve stimulation) produced by these stimulations were significantly smaller in SHR than those in WKY. In another series of experiments, changes in the efferent limb of the baroreflex arc (i.e., greater splanchnic nerve activity) in response to stimulation of the baroreceptor afferents in the aortic nerve were recorded. Inhibition of the greater splanchnic nerve activity due to aortic nerve stimulation was found to be significantly smaller in SHR than in the WKY. Control sympathetic nerve activity was greater in SHR than in WKY. These results suggest that the central bulbospinal nervous system may be another site for resetting of baroreflex in hypertension.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalInternational Journal of Rehabilitation Research
Issue number3
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


  • Aortic nerve
  • Baroceptors
  • Blood pressure
  • Splanchnic nerve


Dive into the research topics of 'Central resetting of baroreflex in the spontaneously hypertensive rat'. Together they form a unique fingerprint.

Cite this