Centrilobular injury following hypoxia in isolated, perfused rat liver

John J. Lemasters, Sungchul Ji, Ronald G. Thurman

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

Hypoxia was produced in isolated, hemoglobin-free, perfused rat liver by reducing the flow rate of oxygen-carrying fluid entering the organ. The procedure caused anoxia in centrilobular regions. In these anoxia areas, structural derangements developed rapidly, characterized by bleb-like protrusions of hepatocyte plasma membrane through fenestrations in the sinusoidal endothelium. Periportal tissue remained normoxic and was completely spared. Cellular injury resulting from localized anoxia may play an important role in the pathogenesis of centrilobular liver disease.

Original languageEnglish (US)
Pages (from-to)661-663
Number of pages3
JournalScience
Volume213
Issue number4508
DOIs
StatePublished - 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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