Chance and necessity in Bacillus subtilis development

Nicolas Mirouze, David Dubnau

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Bacillus subtilis is an important model bacterium for the study of developmental adaptations that enhance survival in the face of fluctuating environmental challenges. These adaptations include sporulation, biofilm formation, motility, cannibalism, and competence. Remarkably, not all the cells in a given population exhibit the same response. The choice of fate by individual cells is random but is also governed by complex signal transduction pathways and cross talk mechanisms that reinforce decisions once made. The interplay of stochastic and deterministic mechanisms governing the selection of developmental fate on the single-cell level is discussed in this article.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalMicrobiology Spectrum
Issue number1
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases


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