Characterization of calcium alginate and chitosan-treated calcium alginate gel beads entrapping allyl isothiocyanate

Won Tae Kim; Hee Chung; Il Shik Shin; Kit L. Yam; Donghwa Chung

doi:10.1016/j.carbpol.2007.06.028

Characterization of calcium alginate and chitosan-treated calcium alginate gel beads entrapping allyl isothiocyanate

Won Tae Kim, Hee Chung, Il Shik Shin, Kit L. Yam, Donghwa Chung

School of Environmental and Biological Sciences, Food Science

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Calcium alginate (CA), chitosan-coated calcium alginate (CCA-I), and chitosan-calcium alginate complex (CCA-II) gel beads, in which an oil-in-water emulsion containing allyl isothiocyanate (AITC) was entrapped, were prepared and characterized for efficient oral delivery of AITC. The AITC entrapment efficiency was 81% for CA gel beads, whereas about 30% lower values were determined for the chitosan-treated gel beads. Swelling studies showed that all the gel beads suddenly shrunk in simulated gastric fluid (pH 1.2). In simulated intestinal fluid (pH 7.4), CA and CCA-I gel beads rapidly disintegrated, whereas CCA-II gel beads highly swelled without degradation probably due to the strong chitosan-alginate complexation. Release studies revealed that most entrapped AITC was released during the shrinkage, degradation, or swelling of the gel beads, and the chitosan treatments, especially the chitosan-alginate complexation, were effective in suppressing the release. CCA-II gel beads showed the highest bead stability and AITC retention under simulated gastrointestinal pH conditions.

Original language	English (US)
Pages (from-to)	566-573
Number of pages	8
Journal	Carbohydrate Polymers
Volume	71
Issue number	4
DOIs	https://doi.org/10.1016/j.carbpol.2007.06.028
State	Published - Mar 7 2008

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Materials Chemistry

Keywords

Allyl isothiocyanate
Calcium alginate
Chitosan
Release
Swelling

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10.1016/j.carbpol.2007.06.028

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title = "Characterization of calcium alginate and chitosan-treated calcium alginate gel beads entrapping allyl isothiocyanate",

abstract = "Calcium alginate (CA), chitosan-coated calcium alginate (CCA-I), and chitosan-calcium alginate complex (CCA-II) gel beads, in which an oil-in-water emulsion containing allyl isothiocyanate (AITC) was entrapped, were prepared and characterized for efficient oral delivery of AITC. The AITC entrapment efficiency was 81% for CA gel beads, whereas about 30% lower values were determined for the chitosan-treated gel beads. Swelling studies showed that all the gel beads suddenly shrunk in simulated gastric fluid (pH 1.2). In simulated intestinal fluid (pH 7.4), CA and CCA-I gel beads rapidly disintegrated, whereas CCA-II gel beads highly swelled without degradation probably due to the strong chitosan-alginate complexation. Release studies revealed that most entrapped AITC was released during the shrinkage, degradation, or swelling of the gel beads, and the chitosan treatments, especially the chitosan-alginate complexation, were effective in suppressing the release. CCA-II gel beads showed the highest bead stability and AITC retention under simulated gastrointestinal pH conditions.",

keywords = "Allyl isothiocyanate, Calcium alginate, Chitosan, Release, Swelling",

author = "Kim, {Won Tae} and Hee Chung and Shin, {Il Shik} and Yam, {Kit L.} and Donghwa Chung",

note = "Funding Information: This work was supported partly by Grant No. RTI05-01-02 from the Regional Technology Innovation Program of the Korean Ministry of Commerce, Industry, and Energy, and partly by 2003 Scientific Research Promoting Grant from the Kangnung National University, Korea. Won-Tae Kim is a recipient of a graduate fellowship from the Brain Korea 21 program of the Korean Ministry of Education and Human Resources Development.",

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AU - Kim, Won Tae

AU - Chung, Hee

AU - Shin, Il Shik

AU - Yam, Kit L.

AU - Chung, Donghwa

N1 - Funding Information: This work was supported partly by Grant No. RTI05-01-02 from the Regional Technology Innovation Program of the Korean Ministry of Commerce, Industry, and Energy, and partly by 2003 Scientific Research Promoting Grant from the Kangnung National University, Korea. Won-Tae Kim is a recipient of a graduate fellowship from the Brain Korea 21 program of the Korean Ministry of Education and Human Resources Development.

PY - 2008/3/7

Y1 - 2008/3/7

N2 - Calcium alginate (CA), chitosan-coated calcium alginate (CCA-I), and chitosan-calcium alginate complex (CCA-II) gel beads, in which an oil-in-water emulsion containing allyl isothiocyanate (AITC) was entrapped, were prepared and characterized for efficient oral delivery of AITC. The AITC entrapment efficiency was 81% for CA gel beads, whereas about 30% lower values were determined for the chitosan-treated gel beads. Swelling studies showed that all the gel beads suddenly shrunk in simulated gastric fluid (pH 1.2). In simulated intestinal fluid (pH 7.4), CA and CCA-I gel beads rapidly disintegrated, whereas CCA-II gel beads highly swelled without degradation probably due to the strong chitosan-alginate complexation. Release studies revealed that most entrapped AITC was released during the shrinkage, degradation, or swelling of the gel beads, and the chitosan treatments, especially the chitosan-alginate complexation, were effective in suppressing the release. CCA-II gel beads showed the highest bead stability and AITC retention under simulated gastrointestinal pH conditions.

AB - Calcium alginate (CA), chitosan-coated calcium alginate (CCA-I), and chitosan-calcium alginate complex (CCA-II) gel beads, in which an oil-in-water emulsion containing allyl isothiocyanate (AITC) was entrapped, were prepared and characterized for efficient oral delivery of AITC. The AITC entrapment efficiency was 81% for CA gel beads, whereas about 30% lower values were determined for the chitosan-treated gel beads. Swelling studies showed that all the gel beads suddenly shrunk in simulated gastric fluid (pH 1.2). In simulated intestinal fluid (pH 7.4), CA and CCA-I gel beads rapidly disintegrated, whereas CCA-II gel beads highly swelled without degradation probably due to the strong chitosan-alginate complexation. Release studies revealed that most entrapped AITC was released during the shrinkage, degradation, or swelling of the gel beads, and the chitosan treatments, especially the chitosan-alginate complexation, were effective in suppressing the release. CCA-II gel beads showed the highest bead stability and AITC retention under simulated gastrointestinal pH conditions.

KW - Allyl isothiocyanate

KW - Calcium alginate

KW - Chitosan

KW - Release

KW - Swelling

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Characterization of calcium alginate and chitosan-treated calcium alginate gel beads entrapping allyl isothiocyanate

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All Science Journal Classification (ASJC) codes

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