Characterization of chemical components of Ixeris denticulata

Hang Chen, Shiming Li, Zhu Zhou, Naisheng Bai, Chi Tang Ho

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The extract of Ixeris denticulata was subjected to successive column chromatography to obtain pure compounds. Five compounds with potential bioactivities were isolated. They were identified as the flavonoids apigenin and luteolin, the sterols β-sitosterol and stigmasterol, and the chlorinated iridoid rehmaglutin D. With the exception of luteolin, the other compounds were reported from Ixeris denticulate for the first time. A systematic investigation on the structure-activity relationships among six flavonoids, namely, quercetin, kaempferol, catechin, epicatechin, apigenin and luteolin was also undertaken, with respect to antioxidant activity. The combined results of DPPH radical scavenging assay and ORAC antioxidant capacity assay indicated the importance of at least four structural elements to the antioxidant activity of these compounds.

Original languageEnglish (US)
Title of host publicationHerbs
Subtitle of host publicationChallenges in Chemistry and Biology
EditorsMingfu Wang, Chi-Tang Ho, Shengmin Sang, Lucy Sun Hwang
Number of pages17
Publication statusPublished - Dec 1 2006

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Chen, H., Li, S., Zhou, Z., Bai, N., & Ho, C. T. (2006). Characterization of chemical components of Ixeris denticulata. In M. Wang, C-T. Ho, S. Sang, & L. S. Hwang (Eds.), Herbs: Challenges in Chemistry and Biology (pp. 195-211). (ACS Symposium Series; Vol. 925).