Characterization of 'foreign' alloantigen-like specificities on a murine lymphoma cell line

J. H. Finke; D. A. Fyfe; B. C. Del Villano; G. H. Butler; Nicholas Ponzio

Characterization of 'foreign' alloantigen-like specificities on a murine lymphoma cell line

J. H. Finke, D. A. Fyfe, B. C. Del Villano, G. H. Butler, Nicholas Ponzio

Research output: Contribution to journal › Article › peer-review

Abstract

We have been studying a murine lymphoma cell line, designated CH-1, that was derived from a spontaneous reticulum cell sarcoma (RCS) of SJL mice and that stimulates a strong syngeneic cytotoxic response in vitro. The mechanism for generating cytotoxic T lymphocytes (CTL) that react with these syngeneic tumor cells is similar to the development of CTL directed against allogeneic cells. The data presented here demonstrate that CH-1 tumor cells express foreign transplantation-like antigens and that these may stimulate syngeneic cytotoxic response.

Original language	English (US)
Pages (from-to)	53-58
Number of pages	6
Journal	Transplantation Proceedings
Volume	12
Issue number	1
State	Published - Dec 31 1980
Externally published	Yes

All Science Journal Classification (ASJC) codes

Surgery
Transplantation

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title = "Characterization of 'foreign' alloantigen-like specificities on a murine lymphoma cell line",

abstract = "We have been studying a murine lymphoma cell line, designated CH-1, that was derived from a spontaneous reticulum cell sarcoma (RCS) of SJL mice and that stimulates a strong syngeneic cytotoxic response in vitro. The mechanism for generating cytotoxic T lymphocytes (CTL) that react with these syngeneic tumor cells is similar to the development of CTL directed against allogeneic cells. The data presented here demonstrate that CH-1 tumor cells express foreign transplantation-like antigens and that these may stimulate syngeneic cytotoxic response.",

author = "Finke, {J. H.} and Fyfe, {D. A.} and {Del Villano}, {B. C.} and Butler, {G. H.} and Nicholas Ponzio",

year = "1980",

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journal = "Transplantation Proceedings",

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T1 - Characterization of 'foreign' alloantigen-like specificities on a murine lymphoma cell line

AU - Finke, J. H.

AU - Fyfe, D. A.

AU - Del Villano, B. C.

AU - Butler, G. H.

AU - Ponzio, Nicholas

PY - 1980/12/31

Y1 - 1980/12/31

N2 - We have been studying a murine lymphoma cell line, designated CH-1, that was derived from a spontaneous reticulum cell sarcoma (RCS) of SJL mice and that stimulates a strong syngeneic cytotoxic response in vitro. The mechanism for generating cytotoxic T lymphocytes (CTL) that react with these syngeneic tumor cells is similar to the development of CTL directed against allogeneic cells. The data presented here demonstrate that CH-1 tumor cells express foreign transplantation-like antigens and that these may stimulate syngeneic cytotoxic response.

AB - We have been studying a murine lymphoma cell line, designated CH-1, that was derived from a spontaneous reticulum cell sarcoma (RCS) of SJL mice and that stimulates a strong syngeneic cytotoxic response in vitro. The mechanism for generating cytotoxic T lymphocytes (CTL) that react with these syngeneic tumor cells is similar to the development of CTL directed against allogeneic cells. The data presented here demonstrate that CH-1 tumor cells express foreign transplantation-like antigens and that these may stimulate syngeneic cytotoxic response.

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