Characterization of 'foreign' alloantigen-like specificities on a murine lymphoma cell line

J. H. Finke, D. A. Fyfe, B. C. Del Villano, G. H. Butler, Nicholas Ponzio

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We have been studying a murine lymphoma cell line, designated CH-1, that was derived from a spontaneous reticulum cell sarcoma (RCS) of SJL mice and that stimulates a strong syngeneic cytotoxic response in vitro. The mechanism for generating cytotoxic T lymphocytes (CTL) that react with these syngeneic tumor cells is similar to the development of CTL directed against allogeneic cells. The data presented here demonstrate that CH-1 tumor cells express foreign transplantation-like antigens and that these may stimulate syngeneic cytotoxic response.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalTransplantation Proceedings
Volume12
Issue number1
StatePublished - Dec 31 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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